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Research Article

Reciprocal Tripartite Interactions between the Aedes aegypti Midgut Microbiota, Innate Immune System and Dengue Virus Influences Vector Competence

  • Jose Luis Ramirez,

    Affiliation: W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America

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  • Jayme Souza-Neto,

    Affiliation: W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America

    Current address: Center for Technological Development in Health (CDTS), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil

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  • Rolando Torres Cosme,

    Affiliation: Gorgas Memorial Institute for Health Research, Panama City, Panama

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  • Jose Rovira,

    Affiliation: Gorgas Memorial Institute for Health Research, Panama City, Panama

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  • Alma Ortiz,

    Affiliation: Gorgas Memorial Institute for Health Research, Panama City, Panama

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  • Juan M. Pascale,

    Affiliation: Gorgas Memorial Institute for Health Research, Panama City, Panama

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  • George Dimopoulos mail

    gdimopou@jhsph.edu

    Affiliation: W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America

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  • Published: March 06, 2012
  • DOI: 10.1371/journal.pntd.0001561

About the Authors

Jose Luis Ramirez, Jayme Souza-Neto, George Dimopoulos
W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America
Rolando Torres Cosme, Jose Rovira, Alma Ortiz, Juan M. Pascale
Gorgas Memorial Institute for Health Research, Panama City, Panama

Corresponding Author

Email: gdimopou@jhsph.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JLR JMP GD. Performed the experiments: JLR JS-N RTC JR AO. Analyzed the data: JLR JMP GD. Contributed reagents/materials/analysis tools: RTC JR. Wrote the paper: JLR GD.