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Research Article

Early Clinical Features of Dengue Virus Infection in Nicaraguan Children: A Longitudinal Analysis

  • Hope H. Biswas,

    Affiliation: Division of Epidemiology, School of Public Health, University of California, Berkeley, California, United States of America

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  • Oscar Ortega,

    Affiliation: Sustainable Sciences Institute, Managua, Nicaragua

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  • Aubree Gordon,

    Affiliations: Division of Epidemiology, School of Public Health, University of California, Berkeley, California, United States of America, Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, California, United States of America

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  • Katherine Standish,

    Affiliation: Sustainable Sciences Institute, Managua, Nicaragua

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  • Angel Balmaseda,

    Affiliation: National Virology Laboratory, Centro Nacional de Diagnóstico y Referencia, Ministry of Health, Managua, Nicaragua

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  • Guillermina Kuan,

    Affiliation: Sócrates Flores Vivas Health Center, Ministry of Health, Managua, Nicaragua

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  • Eva Harris mail

    eharris@berkeley.edu

    Affiliation: Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, California, United States of America

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  • Published: March 06, 2012
  • DOI: 10.1371/journal.pntd.0001562

About the Authors

Hope H. Biswas, Aubree Gordon
Division of Epidemiology, School of Public Health, University of California, Berkeley, California, United States of America
Oscar Ortega, Katherine Standish
Sustainable Sciences Institute, Managua, Nicaragua
Aubree Gordon, Eva Harris
Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, California, United States of America
Angel Balmaseda
National Virology Laboratory, Centro Nacional de Diagnóstico y Referencia, Ministry of Health, Managua, Nicaragua
Guillermina Kuan
Sócrates Flores Vivas Health Center, Ministry of Health, Managua, Nicaragua

Corresponding Author

Email: eharris@berkeley.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HHB OO AG KS EH. Performed the experiments: OO GK. Analyzed the data: HHB OO AG KS. Contributed reagents/materials/analysis tools: AB GK EH. Wrote the paper: HHB KS AG EH.