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Research Article

Enhanced Protective Efficacy of a Chimeric Form of the Schistosomiasis Vaccine Antigen Sm-TSP-2

  • Mark S. Pearson,

    Affiliation: Queensland Tropical Health Alliance and School of Public Health and Tropical Medicine, James Cook University, Cairns, Queensland, Australia

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  • Darren A. Pickering,

    Affiliation: Queensland Tropical Health Alliance and School of Public Health and Tropical Medicine, James Cook University, Cairns, Queensland, Australia

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  • Henry J. McSorley,

    Affiliation: Queensland Tropical Health Alliance and School of Public Health and Tropical Medicine, James Cook University, Cairns, Queensland, Australia

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  • Jeffrey M. Bethony,

    Affiliation: Department of Microbiology, Immunology and Tropical Medicine, George Washington University, Washington D.C., United States of America

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  • Leon Tribolet,

    Affiliation: Queensland Tropical Health Alliance and School of Public Health and Tropical Medicine, James Cook University, Cairns, Queensland, Australia

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  • Annette M. Dougall,

    Affiliation: Queensland Tropical Health Alliance and School of Public Health and Tropical Medicine, James Cook University, Cairns, Queensland, Australia

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  • Peter J. Hotez,

    Affiliation: Department of Pediatrics and Molecular Virology and Microbiology, and National School of Tropical Medicine, Sabin Vaccine Institute and Texas Children's Hospital Center for Vaccine Development, Baylor College of Medicine, Houston, Texas, United States of America

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  • Alex Loukas mail

    alex.loukas@jcu.edu.au

    Affiliation: Queensland Tropical Health Alliance and School of Public Health and Tropical Medicine, James Cook University, Cairns, Queensland, Australia

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  • Published: March 13, 2012
  • DOI: 10.1371/journal.pntd.0001564

About the Authors

Mark S. Pearson, Darren A. Pickering, Henry J. McSorley, Leon Tribolet, Annette M. Dougall, Alex Loukas
Queensland Tropical Health Alliance and School of Public Health and Tropical Medicine, James Cook University, Cairns, Queensland, Australia
Jeffrey M. Bethony
Department of Microbiology, Immunology and Tropical Medicine, George Washington University, Washington D.C., United States of America
Peter J. Hotez
Department of Pediatrics and Molecular Virology and Microbiology, and National School of Tropical Medicine, Sabin Vaccine Institute and Texas Children's Hospital Center for Vaccine Development, Baylor College of Medicine, Houston, Texas, United States of America

Corresponding Author

Email: alex.loukas@jcu.edu.au

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MSP DAP HJM JMB AL. Performed the experiments: MSP DAP HJM JMB LT AMD. Analyzed the data: MSP DAP HJM JMB AL. Contributed reagents/materials/analysis tools: MSP DAP HJM JMB AMD PJH AL. Wrote the paper: MSP HJM JMB PJH AL.