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Research Article

Ebola GP-Specific Monoclonal Antibodies Protect Mice and Guinea Pigs from Lethal Ebola Virus Infection

  • Xiangguo Qiu mail,

    xiangguo.qiu@phac-aspc.gc.ca

    Affiliation: Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada

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  • Lisa Fernando,

    Affiliation: Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada

    X
  • P. Leno Melito,

    Affiliation: Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada

    X
  • Jonathan Audet,

    Affiliations: Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada, Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada

    X
  • Heinz Feldmann,

    Affiliations: Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada, Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada

    Current address: Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America

    X
  • Gary Kobinger,

    Affiliations: Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada, Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada, Department of Immunology, University of Manitoba, Winnipeg, Manitoba, Canada

    X
  • Judie B. Alimonti,

    Affiliations: Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada, Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada

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  • Steven M. Jones

    Affiliations: Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada, Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada, Department of Immunology, University of Manitoba, Winnipeg, Manitoba, Canada

    Current address: Cognoveritas Consulting Inc., Winnipeg, Manitoba, Canada

    X
  • Published: March 20, 2012
  • DOI: 10.1371/journal.pntd.0001575

About the Authors

Xiangguo Qiu, Lisa Fernando, P. Leno Melito, Jonathan Audet, Heinz Feldmann, Gary Kobinger, Judie B. Alimonti, Steven M. Jones
Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
Jonathan Audet, Heinz Feldmann, Gary Kobinger, Judie B. Alimonti, Steven M. Jones
Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
Gary Kobinger, Steven M. Jones
Department of Immunology, University of Manitoba, Winnipeg, Manitoba, Canada

Corresponding Author

Email: xiangguo.qiu@phac-aspc.gc.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: XQ SMJ. Performed the experiments: XQ LF PLM JA HF GK JBA SMJ. Analyzed the data: XQ JA JBA. Contributed reagents/materials/analysis tools: XQ LF PLM JA HF GK JBA SMJ. Wrote the paper: XQ JA JBA.