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Research Article

Density-Dependent Mortality of the Human Host in Onchocerciasis: Relationships between Microfilarial Load and Excess Mortality

  • Martin Walker equal contributor,

    equal contributor Contributed equally to this work with: Martin Walker, Mark P. Little

    Affiliation: Department of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine, Imperial College London, London, United Kingdom

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  • Mark P. Little equal contributor,

    equal contributor Contributed equally to this work with: Martin Walker, Mark P. Little

    Affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, United Kingdom

    Current address: Radiation Epidemiology Branch, National Cancer Institute. Rockville, Maryland, United States of America

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  • Karen S. Wagner,

    Affiliation: Travel and Migrant Health Section, Health Protection Agency Centre for Infections, London, United Kingdom

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  • Edoh W. Soumbey-Alley,

    Affiliation: Health Information Systems, World Health Organization Regional Office for Africa, Brazzaville, Congo

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  • Boakye A. Boatin,

    Affiliation: Special Programme for Research and Training in Tropical Diseases, World Health Organization, Geneva, Switzerland

    Current address: Lymphatic Filariasis Support Centre, Department of Parasitology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana, and Institute of Parasitology, McGill University, Montreal, Canada

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  • María-Gloria Basáñez mail

    m.basanez@imperial.ac.uk

    Affiliation: Department of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine, Imperial College London, London, United Kingdom

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  • Published: March 27, 2012
  • DOI: 10.1371/journal.pntd.0001578

About the Authors

Martin Walker, María-Gloria Basáñez
Department of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine, Imperial College London, London, United Kingdom
Mark P. Little
Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, United Kingdom
Karen S. Wagner
Travel and Migrant Health Section, Health Protection Agency Centre for Infections, London, United Kingdom
Edoh W. Soumbey-Alley
Health Information Systems, World Health Organization Regional Office for Africa, Brazzaville, Congo
Boakye A. Boatin
Special Programme for Research and Training in Tropical Diseases, World Health Organization, Geneva, Switzerland

Corresponding Author

Email: m.basanez@imperial.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Analyzed the data: MW MPL KSW. Wrote the paper: MW MPL M-GB. Managed data collection by the OCP at its headquarters in Burkina Faso: EWSA. Made the data available for analysis as the last OCP director: BAB. Liaised with the OCP for provision of the data and discussed with MW, MPL, and KSW the analysis and interpretation of results: M-GB. Read and approved the final, submitted version: MW MPL KSW EWSA BAB M-GB.