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Research Article

Membrane Cholesterol Regulates Lysosome-Plasma Membrane Fusion Events and Modulates Trypanosoma cruzi Invasion of Host Cells

  • Bárbara Hissa,

    Affiliation: Department of Morphology, Federal University of Minas Gerais, Belo Horizonte, Brazil

    X
  • Jacqueline G. Duarte,

    Affiliation: Department of Morphology, Federal University of Minas Gerais, Belo Horizonte, Brazil

    X
  • Ludmila F. Kelles,

    Affiliation: Department of Morphology, Federal University of Minas Gerais, Belo Horizonte, Brazil

    X
  • Fabio P. Santos,

    Affiliation: Department of Physics, Federal University of Minas Gerais, Belo Horizonte, Brazil

    X
  • Helen L. del Puerto,

    Affiliation: Department of General Pathology, Federal University of Minas Gerais, Belo Horizonte, Brazil

    X
  • Pedro H. Gazzinelli-Guimarães,

    Affiliation: Department of Parasitology, Federal University of Minas Gerais, Belo Horizonte, Brazil

    X
  • Ana M. de Paula,

    Affiliation: Department of Physics, Federal University of Minas Gerais, Belo Horizonte, Brazil

    X
  • Ubirajara Agero,

    Affiliation: Department of Physics, Federal University of Minas Gerais, Belo Horizonte, Brazil

    X
  • Oscar N. Mesquita,

    Affiliation: Department of Physics, Federal University of Minas Gerais, Belo Horizonte, Brazil

    X
  • Cristina Guatimosim,

    Affiliation: Department of Morphology, Federal University of Minas Gerais, Belo Horizonte, Brazil

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  • Egler Chiari,

    Affiliation: Department of Parasitology, Federal University of Minas Gerais, Belo Horizonte, Brazil

    X
  • Luciana O. Andrade mail

    landrade@icb.ufmg.br

    Affiliation: Department of Morphology, Federal University of Minas Gerais, Belo Horizonte, Brazil

    X
  • Published: March 27, 2012
  • DOI: 10.1371/journal.pntd.0001583

About the Authors

Bárbara Hissa, Jacqueline G. Duarte, Ludmila F. Kelles, Cristina Guatimosim, Luciana O. Andrade
Department of Morphology, Federal University of Minas Gerais, Belo Horizonte, Brazil
Fabio P. Santos, Ana M. de Paula, Ubirajara Agero, Oscar N. Mesquita
Department of Physics, Federal University of Minas Gerais, Belo Horizonte, Brazil
Helen L. del Puerto
Department of General Pathology, Federal University of Minas Gerais, Belo Horizonte, Brazil
Pedro H. Gazzinelli-Guimarães, Egler Chiari
Department of Parasitology, Federal University of Minas Gerais, Belo Horizonte, Brazil

Corresponding Author

Email: landrade@icb.ufmg.br

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CG LOA. Performed the experiments: BH JGD LFK FPS HLdP PHG AMdP. Analyzed the data: BH FPS PHG AMdP UA CG LOA. Contributed reagents/materials/analysis tools: UA ONM CG EC LOA. Wrote the paper: BH CG LOA. Designed the software used in analysis: FPS.