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Research Article

Protective Human Leucocyte Antigen Haplotype, HLA-DRB1*01-B*14, against Chronic Chagas Disease in Bolivia

  • Florencia del Puerto,

    Affiliation: Department of Immunogenetics, Institute of Tropical Medicine (NEKKEN), and Global COE Program, Nagasaki University, Nagasaki, Japan

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  • Juan Eiki Nishizawa,

    Affiliation: Clinica Siraní, Santa Cruz, Bolivia

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  • Mihoko Kikuchi,

    Affiliations: Department of Immunogenetics, Institute of Tropical Medicine (NEKKEN), and Global COE Program, Nagasaki University, Nagasaki, Japan, Center for International Collaboration Research (CICORN), Nagasaki University, Nagasaki, Japan

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  • Yelin Roca,

    Affiliation: Centro Nacional de Enfermedades Tropicales, Santa Cruz, Bolivia

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  • Cinthia Avilas,

    Affiliation: Centro Nacional de Enfermedades Tropicales, Santa Cruz, Bolivia

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  • Alberto Gianella,

    Affiliation: Centro Nacional de Enfermedades Tropicales, Santa Cruz, Bolivia

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  • Javier Lora,

    Affiliation: Centro Nacional de Enfermedades Tropicales, Santa Cruz, Bolivia

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  • Freddy Udalrico Gutierrez Velarde,

    Affiliation: Hospital Universitario Japonés, Santa Cruz, Bolivia

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  • Sachio Miura,

    Affiliation: Department of Tropical Medicine and Parasitology, School of Medicine, Keio University, Tokyo, Japan

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  • Norihiro Komiya,

    Affiliation: Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan

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  • Koji Maemura,

    Affiliation: Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan

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  • Kenji Hirayama mail

    hiraken@nagasaki-u.ac.jp

    Affiliation: Department of Immunogenetics, Institute of Tropical Medicine (NEKKEN), and Global COE Program, Nagasaki University, Nagasaki, Japan

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  • Published: March 20, 2012
  • DOI: 10.1371/journal.pntd.0001587

About the Authors

Florencia del Puerto, Mihoko Kikuchi, Kenji Hirayama
Department of Immunogenetics, Institute of Tropical Medicine (NEKKEN), and Global COE Program, Nagasaki University, Nagasaki, Japan
Juan Eiki Nishizawa
Clinica Siraní, Santa Cruz, Bolivia
Mihoko Kikuchi
Center for International Collaboration Research (CICORN), Nagasaki University, Nagasaki, Japan
Yelin Roca, Cinthia Avilas, Alberto Gianella, Javier Lora
Centro Nacional de Enfermedades Tropicales, Santa Cruz, Bolivia
Freddy Udalrico Gutierrez Velarde
Hospital Universitario Japonés, Santa Cruz, Bolivia
Sachio Miura
Department of Tropical Medicine and Parasitology, School of Medicine, Keio University, Tokyo, Japan
Norihiro Komiya, Koji Maemura
Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan

Corresponding Author

Email: hiraken@nagasaki-u.ac.jp

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JEN FUGV SM KH. Performed the experiments: FdP JEN MK YR CA AG JL FUGV. Analyzed the data: MK YR NK KM KH. Contributed reagents/materials/analysis tools: JEN YR FUGV KH. Wrote the paper: FdP JEN MK FUGV KM KH. Diagnostic of Chagas: JEN YR CA AG JL FUGV SM NK KM. Genetic analysis: FdP MK KH.