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Research Article

Investigation of the Proteolytic Functions of an Expanded Cercarial Elastase Gene Family in Schistosoma mansoni

  • Jessica R. Ingram,

    Affiliation: Tetrad Graduate Program, University of California San Francisco, San Francisco, California, United States of America

    Current address: Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America

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  • Salma B. Rafi,

    Affiliation: Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America

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  • A. Alegra Eroy-Reveles,

    Affiliation: Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America

    Current address: Department of Chemistry and Biochemistry, San Francisco State University, San Francisco, California, United States of America

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  • Manisha Ray,

    Affiliation: Tetrad Graduate Program, University of California San Francisco, San Francisco, California, United States of America

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  • Laura Lambeth,

    Affiliation: Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America

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  • Ivy Hsieh,

    Affiliation: Department of Pathology, University of California San Francisco, San Francisco, California, United States of America

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  • Debbie Ruelas,

    Affiliation: Department of Pathology, University of California San Francisco, San Francisco, California, United States of America

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  • K. C. Lim,

    Affiliation: Department of Pathology, University of California San Francisco, San Francisco, California, United States of America

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  • Judy Sakanari,

    Affiliation: Sandler Center for Drug Discovery, University of California San Francisco, San Francisco, California, United States of America

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  • Charles S. Craik,

    Affiliation: Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America

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  • Matthew P. Jacobson,

    Affiliation: Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America

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  • James H. McKerrow mail

    james.mckerrow@ucsf.edu

    Affiliations: Department of Pathology, University of California San Francisco, San Francisco, California, United States of America, Sandler Center for Drug Discovery, University of California San Francisco, San Francisco, California, United States of America

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  • Published: April 03, 2012
  • DOI: 10.1371/journal.pntd.0001589

About the Authors

Jessica R. Ingram, Manisha Ray
Tetrad Graduate Program, University of California San Francisco, San Francisco, California, United States of America
Salma B. Rafi, A. Alegra Eroy-Reveles, Laura Lambeth, Charles S. Craik, Matthew P. Jacobson
Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America
Ivy Hsieh, Debbie Ruelas, K. C. Lim, James H. McKerrow
Department of Pathology, University of California San Francisco, San Francisco, California, United States of America
Judy Sakanari, James H. McKerrow
Sandler Center for Drug Discovery, University of California San Francisco, San Francisco, California, United States of America

Corresponding Author

Email: james.mckerrow@ucsf.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JRI SBR JS MPJ JHM. Performed the experiments: JRI SBR LL IH. Analyzed the data: JRI SBR JS JHM. Contributed reagents/materials/analysis tools: AAE-R MR LL DR KCL CSC. Wrote the paper: JRI JHM.