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Research Article

Severe Dengue Is Associated with Consumption of von Willebrand Factor and Its Cleaving Enzyme ADAMTS-13

  • Kis Djamiatun,

    Affiliation: Department of Parasitology, Faculty of Medicine, Diponegoro University, Semarang, Indonesia

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  • Andre J. A. M. van der Ven,

    Affiliation: Department of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

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  • Philip G. de Groot,

    Affiliation: Laboratory for Thrombosis and Haemostasis, Department of Clinical Chemistry and Haematology, University Medical Centre, Utrecht, The Netherlands

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  • Sultana M. H. Faradz,

    Affiliation: Division of Human Genetics, Faculty of Medicine, Diponegoro University, Semarang, Indonesia

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  • D. Hapsari,

    Affiliation: Department of Pediatrics, Faculty of Medicine, Diponegoro University, Semarang, Indonesia

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  • Wil M. V. Dolmans,

    Affiliation: Department of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

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  • Silvie Sebastian,

    Affiliation: Laboratory for Thrombosis and Haemostasis, Department of Clinical Chemistry and Haematology, University Medical Centre, Utrecht, The Netherlands

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  • Rob Fijnheer,

    Affiliation: Laboratory for Thrombosis and Haemostasis, Department of Clinical Chemistry and Haematology, University Medical Centre, Utrecht, The Netherlands

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  • Quirijn de Mast mail

    q.demast@aig.umcn.nl

    Affiliation: Department of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

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  • Published: May 01, 2012
  • DOI: 10.1371/journal.pntd.0001628

About the Authors

Kis Djamiatun
Department of Parasitology, Faculty of Medicine, Diponegoro University, Semarang, Indonesia
Andre J. A. M. van der Ven, Wil M. V. Dolmans, Quirijn de Mast
Department of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Philip G. de Groot, Silvie Sebastian, Rob Fijnheer
Laboratory for Thrombosis and Haemostasis, Department of Clinical Chemistry and Haematology, University Medical Centre, Utrecht, The Netherlands
Sultana M. H. Faradz
Division of Human Genetics, Faculty of Medicine, Diponegoro University, Semarang, Indonesia
D. Hapsari
Department of Pediatrics, Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Corresponding Author

Email: q.demast@aig.umcn.nl

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KD AJAMV PGG RF SMHF DH WMVD QM. Performed the experiments: SS PGG RF. Analyzed the data: KD QM. Contributed reagents/materials/analysis tools: PGG RF. Wrote the paper: KD QM AJAMV.