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Research Article

Deficient Regulatory T Cell Activity and Low Frequency of IL-17-Producing T Cells Correlate with the Extent of Cardiomyopathy in Human Chagas' Disease

  • Paulo Marcos Matta Guedes equal contributor,

    equal contributor Contributed equally to this work with: Paulo Marcos Matta Guedes, Fredy Roberto Salazar Gutierrez

    Affiliations: Department of Microbiology and Parasitology, Federal University of Rio Grande do Norte, Natal, Brazil, Department of Biochemistry and Immunology, School of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil

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  • Fredy Roberto Salazar Gutierrez equal contributor,

    equal contributor Contributed equally to this work with: Paulo Marcos Matta Guedes, Fredy Roberto Salazar Gutierrez

    Affiliations: Department of Biochemistry and Immunology, School of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil, School of Medicine, University Antonio Narino, Bogota, Colombia

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  • Grace Kelly Silva,

    Affiliation: Department of Biochemistry and Immunology, School of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil

    X
  • Renata Dellalibera-Joviliano,

    Affiliation: Integrated Faculty Fafibe and Department of Surgery and Anatomy, School of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil

    X
  • Gerson Jhonatan Rodrigues,

    Affiliation: Department of Pharmacology, School of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil

    X
  • Lusiane Maria Bendhack,

    Affiliation: Department of Physical and Chemistry, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, São Paulo, Brazil

    X
  • Anis Rassi Jr,

    Affiliation: Division of Cardiology, Anis Rassi Hospital, Goiânia, Brazil

    X
  • Anis Rassi,

    Affiliation: Division of Cardiology, Anis Rassi Hospital, Goiânia, Brazil

    X
  • André Schmidt,

    Affiliation: Division of Cardiology, School of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil

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  • Benedito Carlos Maciel,

    Affiliation: Division of Cardiology, School of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil

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  • José Antonio Marin Neto,

    Affiliation: Division of Cardiology, School of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil

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  • João Santana Silva mail

    jsdsilva@fmrp.usp.br

    Affiliation: Department of Biochemistry and Immunology, School of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil

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  • Published: April 24, 2012
  • DOI: 10.1371/journal.pntd.0001630

About the Authors

Paulo Marcos Matta Guedes
Department of Microbiology and Parasitology, Federal University of Rio Grande do Norte, Natal, Brazil
Paulo Marcos Matta Guedes, Fredy Roberto Salazar Gutierrez, Grace Kelly Silva, João Santana Silva
Department of Biochemistry and Immunology, School of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil
Fredy Roberto Salazar Gutierrez
School of Medicine, University Antonio Narino, Bogota, Colombia
Renata Dellalibera-Joviliano
Integrated Faculty Fafibe and Department of Surgery and Anatomy, School of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil
Gerson Jhonatan Rodrigues
Department of Pharmacology, School of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil
Lusiane Maria Bendhack
Department of Physical and Chemistry, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, São Paulo, Brazil
Anis Rassi Jr, Anis Rassi
Division of Cardiology, Anis Rassi Hospital, Goiânia, Brazil
André Schmidt, Benedito Carlos Maciel, José Antonio Marin Neto
Division of Cardiology, School of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil

Corresponding Author

Email: jsdsilva@fmrp.usp.br

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PMMG FRSG JSS. Performed the experiments: PMMG FRSG GKS. Analyzed the data: PMMG FRSG GKS RDJ GJR LMB AR ARJ AS BCM JAMN JSS. Contributed reagents/materials/analysis tools: PMMG FRSG GKS RDJ GJR LMB AR ARJ AS BCM JAMN JSS. Wrote the paper: PMMG FRSG AR ARJ AS BCM JAMN JSS.