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Research Article

Junín Virus Infection Activates the Type I Interferon Pathway in a RIG-I-Dependent Manner

  • Cheng Huang equal contributor,

    equal contributor Contributed equally to this work with: Cheng Huang, Olga A. Kolokoltsova

    Affiliation: Galveston National Laboratory, Department of Pathology and Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas, United States of America

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  • Olga A. Kolokoltsova equal contributor,

    equal contributor Contributed equally to this work with: Cheng Huang, Olga A. Kolokoltsova

    Affiliation: Galveston National Laboratory, Department of Pathology and Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas, United States of America

    X
  • Nadezdha E. Yun,

    Affiliation: Galveston National Laboratory, Department of Pathology and Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas, United States of America

    X
  • Alexey V. Seregin,

    Affiliation: Galveston National Laboratory, Department of Pathology and Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas, United States of America

    X
  • Allison L. Poussard,

    Affiliation: Galveston National Laboratory, Department of Pathology and Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas, United States of America

    X
  • Aida G. Walker,

    Affiliation: Galveston National Laboratory, Department of Pathology and Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas, United States of America

    X
  • Allan R. Brasier,

    Affiliation: Department of Internal Medicine and Sealy Center for Molecular Medicine, Institute for Translational Sciences, University of Texas Medical Branch, Galveston, Texas, United States of America

    X
  • Yingxin Zhao,

    Affiliation: Department of Internal Medicine and Sealy Center for Molecular Medicine, Institute for Translational Sciences, University of Texas Medical Branch, Galveston, Texas, United States of America

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  • Bing Tian,

    Affiliation: Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas, United States of America

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  • Juan Carlos de la Torre,

    Affiliation: Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America

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  • Slobodan Paessler mail

    slpaessl@utmb.edu

    Affiliation: Galveston National Laboratory, Department of Pathology and Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas, United States of America

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  • Published: May 22, 2012
  • DOI: 10.1371/journal.pntd.0001659

About the Authors

Cheng Huang, Olga A. Kolokoltsova, Nadezdha E. Yun, Alexey V. Seregin, Allison L. Poussard, Aida G. Walker, Slobodan Paessler
Galveston National Laboratory, Department of Pathology and Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas, United States of America
Allan R. Brasier, Yingxin Zhao
Department of Internal Medicine and Sealy Center for Molecular Medicine, Institute for Translational Sciences, University of Texas Medical Branch, Galveston, Texas, United States of America
Bing Tian
Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas, United States of America
Juan Carlos de la Torre
Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America

Corresponding Author

Email: slpaessl@utmb.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CH OAK SP. Performed the experiments: CH OAK NEY AVS ALP AGW YZ BT. Analyzed the data: CH OAK ARB SP. Contributed reagents/materials/analysis tools: YZ BT. Wrote the paper: CH OAK ARB JCDLT SP.