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Research Article

Experimental Induction of Paromomycin Resistance in Antimony-Resistant Strains of L. donovani: Outcome Dependent on In Vitro Selection Protocol

  • Sarah Hendrickx equal contributor,

    equal contributor Contributed equally to this work with: Sarah Hendrickx, Raquel Andrea Inocêncio da Luz

    Affiliation: Laboratory of Microbiology, Parasitology and Hygiene, University of Antwerp, Antwerp, Belgium

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  • Raquel Andrea Inocêncio da Luz equal contributor,

    equal contributor Contributed equally to this work with: Sarah Hendrickx, Raquel Andrea Inocêncio da Luz

    Affiliation: Laboratory of Microbiology, Parasitology and Hygiene, University of Antwerp, Antwerp, Belgium

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  • Vasundhra Bhandari,

    Affiliation: National Institute of Pathology, Safdarjung Hospital Campus, New Delhi, India

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  • Kristel Kuypers,

    Affiliation: Laboratory of Microbiology, Parasitology and Hygiene, University of Antwerp, Antwerp, Belgium

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  • Craig D. Shaw,

    Affiliation: Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom

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  • Julien Lonchamp,

    Affiliation: Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom

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  • Poonam Salotra,

    Affiliation: National Institute of Pathology, Safdarjung Hospital Campus, New Delhi, India

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  • Katharine Carter,

    Affiliation: Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom

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  • Shyam Sundar,

    Affiliation: Institute of Medical Sciences, Banaras Hindu University, Varanasi, India

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  • Suman Rijal,

    Affiliation: BP Koirala Institute of Health Sciences, Dharan, Nepal

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  • Jean-Claude Dujardin,

    Affiliation: Institute of Tropical Medicine Antwerp, Antwerp, Belgium

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  • Paul Cos,

    Affiliation: Laboratory of Microbiology, Parasitology and Hygiene, University of Antwerp, Antwerp, Belgium

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  • Louis Maes mail

    louis.maes@ua.ac.be

    Affiliation: Laboratory of Microbiology, Parasitology and Hygiene, University of Antwerp, Antwerp, Belgium

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  • Published: May 29, 2012
  • DOI: 10.1371/journal.pntd.0001664

About the Authors

Sarah Hendrickx, Raquel Andrea Inocêncio da Luz, Kristel Kuypers, Paul Cos, Louis Maes
Laboratory of Microbiology, Parasitology and Hygiene, University of Antwerp, Antwerp, Belgium
Vasundhra Bhandari, Poonam Salotra
National Institute of Pathology, Safdarjung Hospital Campus, New Delhi, India
Craig D. Shaw, Julien Lonchamp, Katharine Carter
Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom
Shyam Sundar
Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
Suman Rijal
BP Koirala Institute of Health Sciences, Dharan, Nepal
Jean-Claude Dujardin
Institute of Tropical Medicine Antwerp, Antwerp, Belgium

Corresponding Author

Email: louis.maes@ua.ac.be

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SH RAIDL PC LM. Performed the experiments: SH RAIDL VB KK CDS JL. Analyzed the data: SH RAIDL PS KC LM. Contributed reagents/materials/analysis tools: SS SR JCD. Wrote the paper: SH RAIDL PA KC JCD PC LM.