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Research Article

Ciclosporin A Proof of Concept Study in Patients with Active, Progressive HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis

  • Fabiola Martin mail,

    fabiola.martin@hyms.ac.uk

    Affiliation: Centre for Immunology and Infection, Department of Biology, Hull and York Medical School, University of York, York, United Kingdom

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  • Hannah Castro,

    Affiliation: Medical Research Council, Clinical Trials Unit, London, United Kingdom

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  • Carolyn Gabriel,

    Affiliation: Department of Neurology, St Mary's Hospital, London, United Kingdom

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  • Adine Adonis,

    Affiliation: National Centre for Human Retrovirology, St Mary's Hospital, London, United Kingdom

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  • Alexandra Fedina,

    Affiliation: National Centre for Human Retrovirology, St Mary's Hospital, London, United Kingdom

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  • Linda Harrison,

    Affiliation: Medical Research Council, Clinical Trials Unit, London, United Kingdom

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  • Liz Brodnicki,

    Affiliation: Medical Research Council, Clinical Trials Unit, London, United Kingdom

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  • Maria A. Demontis,

    Affiliation: Section of Infectious Diseases, Faculty of Medicine, Imperial College, London, United Kingdom

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  • Abdel G. Babiker,

    Affiliation: Medical Research Council, Clinical Trials Unit, London, United Kingdom

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  • Jonathan N. Weber,

    Affiliations: National Centre for Human Retrovirology, St Mary's Hospital, London, United Kingdom, Section of Infectious Diseases, Faculty of Medicine, Imperial College, London, United Kingdom

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  • Charles R. M. Bangham,

    Affiliation: Section of Infectious Diseases, Faculty of Medicine, Imperial College, London, United Kingdom

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  • Graham P. Taylor

    Affiliations: National Centre for Human Retrovirology, St Mary's Hospital, London, United Kingdom, Section of Infectious Diseases, Faculty of Medicine, Imperial College, London, United Kingdom

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  • Published: June 12, 2012
  • DOI: 10.1371/journal.pntd.0001675

About the Authors

Fabiola Martin
Centre for Immunology and Infection, Department of Biology, Hull and York Medical School, University of York, York, United Kingdom
Hannah Castro, Linda Harrison, Liz Brodnicki, Abdel G. Babiker
Medical Research Council, Clinical Trials Unit, London, United Kingdom
Carolyn Gabriel
Department of Neurology, St Mary's Hospital, London, United Kingdom
Adine Adonis, Alexandra Fedina, Jonathan N. Weber, Graham P. Taylor
National Centre for Human Retrovirology, St Mary's Hospital, London, United Kingdom
Maria A. Demontis, Jonathan N. Weber, Charles R. M. Bangham, Graham P. Taylor
Section of Infectious Diseases, Faculty of Medicine, Imperial College, London, United Kingdom

Corresponding Author

Email: fabiola.martin@hyms.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CG AGB JNW CRMB GPT. Performed the experiments: AMD. Analyzed the data: HC LH LB. Contributed reagents/materials/analysis tools: CRMB GPT. Wrote the paper: FM HC GPT. Trial Clinicians: FM CG AA AF GPT. Virological studies: MAD. Trial Clinical Governance and Data Validation: LB. Data analysis: HC LH. All co-authors contributed to and approved the final version of the manuscript.