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Research Article

Local Increase of Arginase Activity in Lesions of Patients with Cutaneous Leishmaniasis in Ethiopia

  • Tamrat Abebe,

    Affiliations: Department of Microbiology, Immunology and Parasitology, Addis Ababa University, Addis Ababa, Ethiopia, Department of Biochemistry, WHO Immunology Research and Training Center, University of Lausanne, Lausanne, Switzerland

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  • Asrat Hailu,

    Affiliation: Department of Microbiology, Immunology and Parasitology, Addis Ababa University, Addis Ababa, Ethiopia

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  • Mihretu Woldeyes,

    Affiliation: Department of Dermatology and Venerology, Addis Ababa University, Addis Ababa, Ethiopia

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  • Woinshet Mekonen,

    Affiliation: Department of Microbiology, Immunology and Parasitology, Addis Ababa University, Addis Ababa, Ethiopia

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  • Kassahun Bilcha,

    Affiliation: Department of Dermatovenerology, Gondar University, Gondar, Ethiopia

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  • Thomas Cloke,

    Affiliation: Section of Immunology, Department of Medicine, Imperial College London, London, United Kingdom

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  • Lionel Fry,

    Affiliation: Department of Medicine, Imperial College London, London, United Kingdom

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  • Nafisa-Katrin Seich al Basatena,

    Affiliation: Section of Immunology, Department of Medicine, Imperial College London, London, United Kingdom

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  • Karina Corware,

    Affiliation: Section of Immunology, Department of Medicine, Imperial College London, London, United Kingdom

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  • Manuel Modolell,

    Affiliation: Department of Cellular Immunology, Max-Planck-Institute for Immunobiology and Epigenetics, Freiburg, Germany

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  • Markus Munder,

    Affiliation: Third Department of Medicine (Hematology, Oncology, and Pneumology), University Medical Center Mainz, Mainz, Germany

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  • Fabienne Tacchini-Cottier,

    Affiliation: Department of Biochemistry, WHO Immunology Research and Training Center, University of Lausanne, Lausanne, Switzerland

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  • Ingrid Müller equal contributor mail,

    equal contributor Contributed equally to this work with: Ingrid Müller, Pascale Kropf

    i.muller@imperial.ac.uk (IM); Pascale.Kropf@lshtm.ac.uk (PK)

    Affiliation: Section of Immunology, Department of Medicine, Imperial College London, London, United Kingdom

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  • Pascale Kropf equal contributor mail

    equal contributor Contributed equally to this work with: Ingrid Müller, Pascale Kropf

    i.muller@imperial.ac.uk (IM); Pascale.Kropf@lshtm.ac.uk (PK)

    Affiliation: Infection and Immunology Department, London School of Hygiene and Tropical Medicine, London, United Kingdom

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  • Published: June 12, 2012
  • DOI: 10.1371/journal.pntd.0001684

About the Authors

Tamrat Abebe, Asrat Hailu, Woinshet Mekonen
Department of Microbiology, Immunology and Parasitology, Addis Ababa University, Addis Ababa, Ethiopia
Tamrat Abebe, Fabienne Tacchini-Cottier
Department of Biochemistry, WHO Immunology Research and Training Center, University of Lausanne, Lausanne, Switzerland
Mihretu Woldeyes
Department of Dermatology and Venerology, Addis Ababa University, Addis Ababa, Ethiopia
Kassahun Bilcha
Department of Dermatovenerology, Gondar University, Gondar, Ethiopia
Thomas Cloke, Nafisa-Katrin Seich al Basatena, Karina Corware, Ingrid Müller
Section of Immunology, Department of Medicine, Imperial College London, London, United Kingdom
Lionel Fry
Department of Medicine, Imperial College London, London, United Kingdom
Manuel Modolell
Department of Cellular Immunology, Max-Planck-Institute for Immunobiology and Epigenetics, Freiburg, Germany
Markus Munder
Third Department of Medicine (Hematology, Oncology, and Pneumology), University Medical Center Mainz, Mainz, Germany
Pascale Kropf
Infection and Immunology Department, London School of Hygiene and Tropical Medicine, London, United Kingdom

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TA AH IM PK. Performed the experiments: TA MW WM TC KC PK. Analyzed the data: TA AH KB TC NKSaB LF M. Modolell M. Munder FTC IM PK. Wrote the paper: TA IM PK.