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Research Article

Footprint of Positive Selection in Treponema pallidum subsp. pallidum Genome Sequences Suggests Adaptive Microevolution of the Syphilis Pathogen

  • Lorenzo Giacani equal contributor mail,

    equal contributor Contributed equally to this work with: Lorenzo Giacani, Sujay Chattopadhyay

    giacal@u.washington.edu

    Affiliation: Department of Medicine, University of Washington, Seattle, Washington, United States of America

    X
  • Sujay Chattopadhyay equal contributor,

    equal contributor Contributed equally to this work with: Lorenzo Giacani, Sujay Chattopadhyay

    Affiliation: Department of Microbiology, University of Washington, Seattle, Washington, United States of America

    X
  • Arturo Centurion-Lara,

    Affiliation: Department of Medicine, University of Washington, Seattle, Washington, United States of America

    X
  • Brendan M. Jeffrey,

    Affiliation: Department of Biomedical Sciences, Oregon State University, Corvallis, Oregon, United States of America

    X
  • Hoavan T. Le,

    Affiliation: Department of Medicine, University of Washington, Seattle, Washington, United States of America

    X
  • Barbara J. Molini,

    Affiliation: Department of Medicine, University of Washington, Seattle, Washington, United States of America

    X
  • Sheila A. Lukehart,

    Affiliations: Department of Medicine, University of Washington, Seattle, Washington, United States of America, Department of Global Health, University of Washington, Seattle, Washington, United States of America

    X
  • Evgeni V. Sokurenko,

    Affiliation: Department of Microbiology, University of Washington, Seattle, Washington, United States of America

    X
  • Daniel D. Rockey

    Affiliation: Department of Biomedical Sciences, Oregon State University, Corvallis, Oregon, United States of America

    X
  • Published: June 12, 2012
  • DOI: 10.1371/journal.pntd.0001698

About the Authors

Lorenzo Giacani, Arturo Centurion-Lara, Hoavan T. Le, Barbara J. Molini, Sheila A. Lukehart
Department of Medicine, University of Washington, Seattle, Washington, United States of America
Sujay Chattopadhyay, Evgeni V. Sokurenko
Department of Microbiology, University of Washington, Seattle, Washington, United States of America
Brendan M. Jeffrey, Daniel D. Rockey
Department of Biomedical Sciences, Oregon State University, Corvallis, Oregon, United States of America
Sheila A. Lukehart
Department of Global Health, University of Washington, Seattle, Washington, United States of America

Corresponding Author

Email: giacal@u.washington.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LG ACL SAL DDR. Performed the experiments: LG BMJ BJM. Analyzed the data: LG SC ACL HTL SAL EVS DDR. Wrote the paper: LG SC ACL BMJ HTL SAL EVS.