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Research Article

Safety and Immunogenicity of rSh28GST Antigen in Humans: Phase 1 Randomized Clinical Study of a Vaccine Candidate against Urinary Schistosomiasis

  • Gilles Riveau mail,

    gilles.riveau@gmail.com

    Affiliation: Inserm – Université Lille 2, Institut Pasteur de Lille, Lille, France

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  • Dominique Deplanque,

    Affiliations: Inserm CIC-CRB 9301, CHRU, Lille, France, Université Lille – Nord de France, Département de Pharmacologie Médicale, Faculté de Médecine, Lille, France

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  • Franck Remoué,

    Affiliation: Inserm – Université Lille 2, Institut Pasteur de Lille, Lille, France

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  • Anne-Marie Schacht,

    Affiliation: Inserm – Université Lille 2, Institut Pasteur de Lille, Lille, France

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  • Hubert Vodougnon,

    Affiliation: Inserm CIC-CRB 9301, CHRU, Lille, France

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  • Monique Capron,

    Affiliation: Inserm – Université Lille 2, Institut Pasteur de Lille, Lille, France

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  • Michel Thiry,

    Affiliation: Eurogentec, Parc Scientifique, Seraing, Belgium

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  • Joseph Martial,

    Affiliation: Eurogentec, Parc Scientifique, Seraing, Belgium

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  • Christian Libersa,

    Affiliations: Inserm CIC-CRB 9301, CHRU, Lille, France, Université Lille – Nord de France, Département de Pharmacologie Médicale, Faculté de Médecine, Lille, France

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  • André Capron

    Affiliation: Inserm – Université Lille 2, Institut Pasteur de Lille, Lille, France

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  • Published: July 03, 2012
  • DOI: 10.1371/journal.pntd.0001704

About the Authors

Gilles Riveau, Franck Remoué, Anne-Marie Schacht, Monique Capron, André Capron
Inserm – Université Lille 2, Institut Pasteur de Lille, Lille, France
Dominique Deplanque, Hubert Vodougnon, Christian Libersa
Inserm CIC-CRB 9301, CHRU, Lille, France
Dominique Deplanque, Christian Libersa
Université Lille – Nord de France, Département de Pharmacologie Médicale, Faculté de Médecine, Lille, France
Michel Thiry, Joseph Martial
Eurogentec, Parc Scientifique, Seraing, Belgium

Corresponding Author

Email: gilles.riveau@gmail.com

Competing Interests

The authors declare that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GR AMS JM CL AC. Performed the experiments: FR AMS MT HV CL. Analyzed the data: GR DD FR AMS HV AC. Contributed reagents/materials/analysis tools: MC MT JM. Wrote the paper: GR DD FR MC AC. Managed the project presentation to ethical committee and to Inserm for funds: GR MC CL.