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Research Article

Administration of Triclabendazole Is Safe and Effective in Controlling Fascioliasis in an Endemic Community of the Bolivian Altiplano

  • Fidel Villegas,

    Affiliation: Veterinary Public Health, Pan American Health Organization/World Health Organization, La Paz, Bolivia

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  • René Angles,

    Affiliation: Faculty of Medicine, Universidad Mayor de San Andrés, La Paz, Bolivia

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  • René Barrientos,

    Affiliation: Servicio Departamental de Salud/SEDES – La Paz, La Paz, Bolivia

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  • Gary Barrios,

    Affiliation: Programa Nacional de Zoonosis – Ministerio de Salud y Deportes, La Paz, Bolivia

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  • María Adela Valero,

    Affiliation: Parasitology Department, Faculty of Pharmacy, Universidad de Valencia, Valencia, Spain

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  • Kamal Hamed,

    Affiliation: Tropical Medicines, Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, United States of America

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  • Heiner Grueninger,

    Affiliation: Tropical Medicines, Novartis Pharma AG, Basel, Switzerland

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  • Steven K. Ault,

    Affiliation: Regional Program on Neglected Infectious Diseases, Pan American Health Organization/World Health Organization, Washington, D.C., United States of America

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  • Antonio Montresor,

    Affiliation: Neglected Tropical Diseases, World Health Organization, Geneva, Switzerland

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  • Dirk Engels,

    Affiliation: Neglected Tropical Diseases, World Health Organization, Geneva, Switzerland

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  • Santiago Mas-Coma,

    Affiliation: Parasitology Department, Faculty of Pharmacy, Universidad de Valencia, Valencia, Spain

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  • Albis Francesco Gabrielli mail

    gabriellia@who.int

    Affiliation: Neglected Tropical Diseases, World Health Organization, Geneva, Switzerland

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  • Published: August 07, 2012
  • DOI: 10.1371/journal.pntd.0001720

About the Authors

Fidel Villegas
Veterinary Public Health, Pan American Health Organization/World Health Organization, La Paz, Bolivia
René Angles
Faculty of Medicine, Universidad Mayor de San Andrés, La Paz, Bolivia
René Barrientos
Servicio Departamental de Salud/SEDES – La Paz, La Paz, Bolivia
Gary Barrios
Programa Nacional de Zoonosis – Ministerio de Salud y Deportes, La Paz, Bolivia
María Adela Valero, Santiago Mas-Coma
Parasitology Department, Faculty of Pharmacy, Universidad de Valencia, Valencia, Spain
Kamal Hamed
Tropical Medicines, Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, United States of America
Heiner Grueninger
Tropical Medicines, Novartis Pharma AG, Basel, Switzerland
Steven K. Ault
Regional Program on Neglected Infectious Diseases, Pan American Health Organization/World Health Organization, Washington, D.C., United States of America
Antonio Montresor, Dirk Engels, Albis Francesco Gabrielli
Neglected Tropical Diseases, World Health Organization, Geneva, Switzerland

Corresponding Author

Email: gabriellia@who.int

Competing Interests

The authors, with the exception of KH and HG, have declared that no competing interests exist. KH and HG are employees of Novartis Pharmaceuticals Corporation and Novartis Pharma AG, respectively. Please note however that drugs are donated free-of-charge to endemic countries, and that therefore a financial gain is not expected. No funds were provided by Novartis Pharmaceuticals Corporation and/or Novartis Pharma AG for the realization of this study.

Author Contributions

Conceived and designed the experiments: FV RA MAV SKA AM DE SMC AFG. Performed the experiments: FV RA RB GB MAV SMC. Analyzed the data: FV RA RB GB MAV SKA AM DE SMC AFG. Contributed reagents/materials/analysis tools: FV RA RB GB MAV KH HG SKA AM DE SMC AFG. Wrote the paper: FV RA MAV SMC AFG. Revised the manuscript: RB GB KH HG SKA AM DE. Facilitated shipment of TCZ tablets: KH HG.