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Research Article

Efficacy of Praziquantel against Schistosoma mekongi and Opisthorchis viverrini: A Randomized, Single-Blinded Dose-Comparison Trial

  • Leonore Lovis equal contributor,

    equal contributor Contributed equally to this work with: Leonore Lovis, Tippi K. Mak

    Affiliation: Laboratory of Parasitology, University of Neuchâtel, Neuchâtel, Switzerland

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  • Tippi K. Mak equal contributor,

    equal contributor Contributed equally to this work with: Leonore Lovis, Tippi K. Mak

    Affiliations: Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland

    X
  • Khampheng Phongluxa,

    Affiliations: Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland, National Institute of Public Health, Vientiane, Lao People’s Democratic Republic

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  • Phonepasong Ayé Soukhathammavong,

    Affiliations: Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland, National Institute of Public Health, Vientiane, Lao People’s Democratic Republic

    X
  • Youthanavanh Vonghachack,

    Affiliations: Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland, Parasitology Unit, Faculty of Basic Sciences, University of Health Sciences, Vientiane, Lao People’s Democratic Republic

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  • Jennifer Keiser,

    Affiliations: University of Basel, Basel, Switzerland, Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland

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  • Penelope Vounatsou,

    Affiliations: Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland

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  • Marcel Tanner,

    Affiliations: Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland

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  • Christoph Hatz,

    Affiliations: University of Basel, Basel, Switzerland, Department of Medical Services and Diagnostic, Swiss Tropical and Public Health Institute, Basel, Switzerland, Institute of Social and Preventive Medicine, University of Zurich, Zurich, Switzerland

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  • Jürg Utzinger,

    Affiliations: Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland

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  • Peter Odermatt mail,

    peter.odermatt@unibas.ch

    Affiliations: Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland

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  • Kongsap Akkhavong

    Affiliation: National Institute of Public Health, Vientiane, Lao People’s Democratic Republic

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  • Published: July 24, 2012
  • DOI: 10.1371/journal.pntd.0001726

About the Authors

Leonore Lovis
Laboratory of Parasitology, University of Neuchâtel, Neuchâtel, Switzerland
Tippi K. Mak, Khampheng Phongluxa, Phonepasong Ayé Soukhathammavong, Youthanavanh Vonghachack, Penelope Vounatsou, Marcel Tanner, Jürg Utzinger, Peter Odermatt
Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland
Tippi K. Mak, Khampheng Phongluxa, Phonepasong Ayé Soukhathammavong, Youthanavanh Vonghachack, Jennifer Keiser, Penelope Vounatsou, Marcel Tanner, Christoph Hatz, Jürg Utzinger, Peter Odermatt
University of Basel, Basel, Switzerland
Khampheng Phongluxa, Phonepasong Ayé Soukhathammavong, Kongsap Akkhavong
National Institute of Public Health, Vientiane, Lao People’s Democratic Republic
Youthanavanh Vonghachack
Parasitology Unit, Faculty of Basic Sciences, University of Health Sciences, Vientiane, Lao People’s Democratic Republic
Jennifer Keiser
Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland
Christoph Hatz
Department of Medical Services and Diagnostic, Swiss Tropical and Public Health Institute, Basel, Switzerland
Christoph Hatz
Institute of Social and Preventive Medicine, University of Zurich, Zurich, Switzerland

Corresponding Author

Email: peter.odermatt@unibas.ch

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JU CH TKM LL PO JK. Performed the experiments: TKM LL KP PAS YV KA. Analyzed the data: LL TKM PV MT JU. Wrote the paper: LL. Overall supervision of the study in Switzerland: MT PO. Overall supervision of the study in Lao PDR: KA. Supervised field survey in Lao PDR: TKM LL KP PAS YV KA. Statistical analysis: LL TKM PV. Critical review of the manuscript: TKM LL JU PO JK CH. Obtained funding: PO.