Advertisement
Research Article

Ascorbic Acid Has Superior Ex Vivo Antiproliferative, Cell Death-Inducing and Immunomodulatory Effects over IFN-α in HTLV-1-Associated Myelopathy

  • Britta Moens mail,

    moensbritta@gmail.com

    Affiliation: Rega Institute for Medical Research, K. U. Leuven, Leuven, Belgium

    X
  • Daniele Decanine,

    Affiliation: Gonçalo Moniz Research Center, Oswaldo Cruz Foundation (FIOCRUZ), Salvador-Bahia, Brazil

    Current address: Universidade Católica Dom Bosco, Campo Grande, Brazil

    X
  • Soraya Maria Menezes,

    Affiliation: Rega Institute for Medical Research, K. U. Leuven, Leuven, Belgium

    X
  • Ricardo Khouri,

    Affiliations: Rega Institute for Medical Research, K. U. Leuven, Leuven, Belgium, Gonçalo Moniz Research Center, Oswaldo Cruz Foundation (FIOCRUZ), Salvador-Bahia, Brazil

    X
  • Gilvanéia Silva-Santos,

    Affiliation: Gonçalo Moniz Research Center, Oswaldo Cruz Foundation (FIOCRUZ), Salvador-Bahia, Brazil

    Current address: Nucleo de Tecnologia em Saúde, Universidade Federal de Bahia, Salvador-Bahia, Brazil

    X
  • Giovanni Lopez,

    Affiliation: Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru

    X
  • Carolina Alvarez,

    Affiliations: Rega Institute for Medical Research, K. U. Leuven, Leuven, Belgium, Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru

    X
  • Michael Talledo,

    Affiliation: Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru

    X
  • Eduardo Gotuzzo,

    Affiliations: Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru, Departamento de Medicina, Facultad de Medicina, Universidad Peruana Cayetano Heredia, Lima, Peru

    X
  • Ramon de Almeida Kruschewsky,

    Affiliation: Bahia School of Medicine and Public Health, Salvador-Bahia, Brazil

    X
  • Bernardo Galvão-Castro,

    Affiliations: Gonçalo Moniz Research Center, Oswaldo Cruz Foundation (FIOCRUZ), Salvador-Bahia, Brazil, Bahia School of Medicine and Public Health, Salvador-Bahia, Brazil

    X
  • Anne-Mieke Vandamme,

    Affiliations: Rega Institute for Medical Research, K. U. Leuven, Leuven, Belgium, Centro de Malária e outras Doenças Tropicais, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisboa, Portugal

    X
  • Johan Van Weyenbergh

    Affiliations: Rega Institute for Medical Research, K. U. Leuven, Leuven, Belgium, Gonçalo Moniz Research Center, Oswaldo Cruz Foundation (FIOCRUZ), Salvador-Bahia, Brazil

    X
  • Published: July 24, 2012
  • DOI: 10.1371/journal.pntd.0001729

About the Authors

Britta Moens, Soraya Maria Menezes, Ricardo Khouri, Carolina Alvarez, Anne-Mieke Vandamme, Johan Van Weyenbergh
Rega Institute for Medical Research, K. U. Leuven, Leuven, Belgium
Daniele Decanine, Ricardo Khouri, Gilvanéia Silva-Santos, Bernardo Galvão-Castro, Johan Van Weyenbergh
Gonçalo Moniz Research Center, Oswaldo Cruz Foundation (FIOCRUZ), Salvador-Bahia, Brazil
Giovanni Lopez, Carolina Alvarez, Michael Talledo, Eduardo Gotuzzo
Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru
Eduardo Gotuzzo
Departamento de Medicina, Facultad de Medicina, Universidad Peruana Cayetano Heredia, Lima, Peru
Ramon de Almeida Kruschewsky, Bernardo Galvão-Castro
Bahia School of Medicine and Public Health, Salvador-Bahia, Brazil
Anne-Mieke Vandamme
Centro de Malária e outras Doenças Tropicais, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisboa, Portugal

Corresponding Author

Email: moensbritta@gmail.com

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BM DD JVW. Performed the experiments: BM DD SMM RK GSS GL MT. Analyzed the data: BM CA JVW. Contributed reagents/materials/analysis tools: EG RAK BGC AV. Wrote the paper: BM JVW AV.