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Research Article

Pharmacology of DB844, an Orally Active aza Analogue of Pafuramidine, in a Monkey Model of Second Stage Human African Trypanosomiasis

  • John K. Thuita mail,

    thuitajk@yahoo.com (JKT); Reto.brun@unibas.ch (RB)

    Affiliation: Trypanosomiasis Research Centre, Kenya Agricultural Research Institute (TRC-KARI), Kikuyu, Kenya

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  • Michael Z. Wang,

    Affiliation: Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, Kansas, United States of America

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  • John M. Kagira,

    Affiliation: Trypanosomiasis Research Centre, Kenya Agricultural Research Institute (TRC-KARI), Kikuyu, Kenya

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  • Cathrine L. Denton,

    Affiliation: Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Mary F. Paine,

    Affiliation: Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Raymond E. Mdachi,

    Affiliation: Trypanosomiasis Research Centre, Kenya Agricultural Research Institute (TRC-KARI), Kikuyu, Kenya

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  • Grace A. Murilla,

    Affiliation: Trypanosomiasis Research Centre, Kenya Agricultural Research Institute (TRC-KARI), Kikuyu, Kenya

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  • Shelley Ching,

    Affiliation: SVC Associates, Inc., Apex, North Carolina, United States of America

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  • David W. Boykin,

    Affiliation: Chemistry Department, Georgia State University, Atlanta, Georgia, United States of America

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  • Richard R. Tidwell,

    Affiliation: Pathology Department, School of Medicine, University of North Carolina at Chapel Hill, North Carolina, United States of America

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  • James E. Hall,

    Affiliation: Pathology Department, School of Medicine, University of North Carolina at Chapel Hill, North Carolina, United States of America

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  • Reto Brun mail

    thuitajk@yahoo.com (JKT); Reto.brun@unibas.ch (RB)

    Affiliation: Swiss Tropical and Public Health Institute and University of Basel, Basel, Switzerland

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  • Published: July 24, 2012
  • DOI: 10.1371/journal.pntd.0001734

About the Authors

John K. Thuita, John M. Kagira, Raymond E. Mdachi, Grace A. Murilla
Trypanosomiasis Research Centre, Kenya Agricultural Research Institute (TRC-KARI), Kikuyu, Kenya
Michael Z. Wang
Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, Kansas, United States of America
Cathrine L. Denton, Mary F. Paine
Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
Shelley Ching
SVC Associates, Inc., Apex, North Carolina, United States of America
David W. Boykin
Chemistry Department, Georgia State University, Atlanta, Georgia, United States of America
Richard R. Tidwell, James E. Hall
Pathology Department, School of Medicine, University of North Carolina at Chapel Hill, North Carolina, United States of America
Reto Brun
Swiss Tropical and Public Health Institute and University of Basel, Basel, Switzerland

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JKT RB GAM JEH MZW RRT. Performed the experiments: JKT JMK REM MZW. Analyzed the data: JKT CLD MZW MFP. Contributed reagents/materials/analysis tools: RRT DWB GAM RB. Wrote the paper: JKT MZW CLD MFP RB SC GAM JEH JMK.