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Research Article

Diverse Inhibitor Chemotypes Targeting Trypanosoma cruzi CYP51

  • Shamila S. Gunatilleke equal contributor,

    equal contributor Contributed equally to this work with: Shamila S. Gunatilleke, Claudia M. Calvet

    Affiliations: Sandler Center for Drug Discovery, University of California San Francisco, San Francisco, California, United States of America, Department of Pathology, University of California San Francisco, San Francisco, California, United States of America

    X
  • Claudia M. Calvet equal contributor,

    equal contributor Contributed equally to this work with: Shamila S. Gunatilleke, Claudia M. Calvet

    Affiliations: Sandler Center for Drug Discovery, University of California San Francisco, San Francisco, California, United States of America, Cellular Ultra-Structure Laboratory, Oswaldo Cruz Institute (IOC), FIOCRUZ, Rio de Janeiro, Rio de Janeiro, Brazil

    X
  • Jonathan B. Johnston,

    Affiliation: Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America

    X
  • Chiung-Kuang Chen,

    Affiliations: Sandler Center for Drug Discovery, University of California San Francisco, San Francisco, California, United States of America, Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America

    X
  • Grigori Erenburg,

    Affiliation: King's University College at the University of Western Ontario, London, Ontario, Canada

    X
  • Jiri Gut,

    Affiliations: Sandler Center for Drug Discovery, University of California San Francisco, San Francisco, California, United States of America, Department of Pathology, University of California San Francisco, San Francisco, California, United States of America, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

    X
  • Juan C. Engel,

    Affiliations: Sandler Center for Drug Discovery, University of California San Francisco, San Francisco, California, United States of America, Department of Pathology, University of California San Francisco, San Francisco, California, United States of America

    X
  • Kenny K. H. Ang,

    Affiliation: Small Molecule Discovery Center, University of California San Francisco, San Francisco, California, United States of America

    X
  • Joseph Mulvaney,

    Affiliation: Small Molecule Discovery Center, University of California San Francisco, San Francisco, California, United States of America

    X
  • Steven Chen,

    Affiliation: Small Molecule Discovery Center, University of California San Francisco, San Francisco, California, United States of America

    X
  • Michelle R. Arkin,

    Affiliation: Small Molecule Discovery Center, University of California San Francisco, San Francisco, California, United States of America

    X
  • James H. McKerrow,

    Affiliations: Sandler Center for Drug Discovery, University of California San Francisco, San Francisco, California, United States of America, Department of Pathology, University of California San Francisco, San Francisco, California, United States of America

    X
  • Larissa M. Podust mail

    larissa.podust@ucsf.edu

    Affiliations: Sandler Center for Drug Discovery, University of California San Francisco, San Francisco, California, United States of America, Department of Pathology, University of California San Francisco, San Francisco, California, United States of America

    X
  • Published: July 31, 2012
  • DOI: 10.1371/journal.pntd.0001736

About the Authors

Shamila S. Gunatilleke, Claudia M. Calvet, Chiung-Kuang Chen, Jiri Gut, Juan C. Engel, James H. McKerrow, Larissa M. Podust
Sandler Center for Drug Discovery, University of California San Francisco, San Francisco, California, United States of America
Shamila S. Gunatilleke, Jiri Gut, Juan C. Engel, James H. McKerrow, Larissa M. Podust
Department of Pathology, University of California San Francisco, San Francisco, California, United States of America
Claudia M. Calvet
Cellular Ultra-Structure Laboratory, Oswaldo Cruz Institute (IOC), FIOCRUZ, Rio de Janeiro, Rio de Janeiro, Brazil
Jonathan B. Johnston, Chiung-Kuang Chen
Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America
Grigori Erenburg
King's University College at the University of Western Ontario, London, Ontario, Canada
Jiri Gut
Department of Medicine, University of California San Francisco, San Francisco, California, United States of America
Kenny K. H. Ang, Joseph Mulvaney, Steven Chen, Michelle R. Arkin
Small Molecule Discovery Center, University of California San Francisco, San Francisco, California, United States of America

Corresponding Author

Email: larissa.podust@ucsf.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JHM MRA LMP. Performed the experiments: SSG CMC JBJ CKC JG JCE KKHA. Analyzed the data: SSG CMC JBJ CKC GE KKHA JM SC LMP. Contributed reagents/materials/analysis tools: JBJ GE JCE JM SC MRA JHM LMP. Wrote the paper: SSG CMC LMP.