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Research Article

Leishmania major Infection in Humanized Mice Induces Systemic Infection and Provokes a Nonprotective Human Immune Response

  • Anja Kathrin Wege,

    Affiliation: Institute of Immunology, University of Regensburg, Regensburg, Bavaria, Germany

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  • Christian Florian,

    Affiliation: Institute of Immunology, University of Regensburg, Regensburg, Bavaria, Germany

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  • Wolfgang Ernst,

    Affiliation: Clinic of Gynecology and Obstetrics St. Hedwig, University of Regensburg, Regensburg, Germany

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  • Nicole Zimara,

    Affiliation: Institute of Immunology, University of Regensburg, Regensburg, Bavaria, Germany

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  • Ulrike Schleicher,

    Affiliation: Microbiology Institute-Clinical Microbiology, Immunology and Hygiene, University Hospital of Erlangen and Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany

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  • Frank Hanses,

    Affiliation: Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany

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  • Maximilian Schmid,

    Affiliation: Institute of Immunology, University of Regensburg, Regensburg, Bavaria, Germany

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  • Uwe Ritter mail

    Uwe.Ritter@klinik.uni-regensburg.de

    Affiliation: Institute of Immunology, University of Regensburg, Regensburg, Bavaria, Germany

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  • Published: July 24, 2012
  • DOI: 10.1371/journal.pntd.0001741

About the Authors

Anja Kathrin Wege, Christian Florian, Nicole Zimara, Maximilian Schmid, Uwe Ritter
Institute of Immunology, University of Regensburg, Regensburg, Bavaria, Germany
Wolfgang Ernst
Clinic of Gynecology and Obstetrics St. Hedwig, University of Regensburg, Regensburg, Germany
Ulrike Schleicher
Microbiology Institute-Clinical Microbiology, Immunology and Hygiene, University Hospital of Erlangen and Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany
Frank Hanses
Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany

Corresponding Author

Email: Uwe.Ritter@klinik.uni-regensburg.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AKW UR. Performed the experiments: WE AKW CF NZ MS US FH. Analyzed the data: AKW UR WE US FH. Contributed reagents/materials/analysis tools: AKW UR. Wrote the paper: AKW UR.