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Research Article

Primary Vaccination with Low Dose Live Dengue 1 Virus Generates a Proinflammatory, Multifunctional T Cell Response in Humans

  • Janet C. Lindow mail,

    janet.lindow@uvm.edu

    Affiliation: Vaccine Testing Center and Unit of Infectious Diseases, Department of Medicine, University of Vermont College of Medicine, Burlington, Vermont, United States of America

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  • Nathan Borochoff-Porte,

    Affiliation: Vaccine Testing Center and Unit of Infectious Diseases, Department of Medicine, University of Vermont College of Medicine, Burlington, Vermont, United States of America

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  • Anna P. Durbin,

    Affiliation: Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America

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  • Stephen S. Whitehead,

    Affiliation: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Kelly A. Fimlaid,

    Affiliation: Vaccine Testing Center and Unit of Infectious Diseases, Department of Medicine, University of Vermont College of Medicine, Burlington, Vermont, United States of America

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  • Janice Y. Bunn,

    Affiliation: University of Vermont College of Mathematics, Burlington, Vermont, United States of America

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  • Beth D. Kirkpatrick

    Affiliation: Vaccine Testing Center and Unit of Infectious Diseases, Department of Medicine, University of Vermont College of Medicine, Burlington, Vermont, United States of America

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  • Published: July 17, 2012
  • DOI: 10.1371/journal.pntd.0001742

About the Authors

Janet C. Lindow, Nathan Borochoff-Porte, Kelly A. Fimlaid, Beth D. Kirkpatrick
Vaccine Testing Center and Unit of Infectious Diseases, Department of Medicine, University of Vermont College of Medicine, Burlington, Vermont, United States of America
Anna P. Durbin
Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
Stephen S. Whitehead
Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
Janice Y. Bunn
University of Vermont College of Mathematics, Burlington, Vermont, United States of America

Corresponding Author

Email: janet.lindow@uvm.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JCL. Performed the experiments: NB-P JCL KAF. Analyzed the data: JCL. Contributed reagents/materials/analysis tools: APD SSW JYB BDK. Wrote the paper: JCL.