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Therapeutics for Dengue: Recommendations for Design and Conduct of Early-Phase Clinical Trials

  • Cameron P. Simmons mail,

    csimmons@oucru.org

    Affiliations: Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam, Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

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  • Marcel Wolbers,

    Affiliations: Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam, Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

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  • Minh Nguyet Nguyen,

    Affiliation: Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam

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  • Jamie Whitehorn,

    Affiliations: Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam, London School of Hygiene and Tropical Medicine, London, United Kingdom

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  • Pei Yong Shi,

    Affiliation: Novartis Institute for Tropical Diseases, Biopolis Way, Singapore

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  • Paul Young,

    Affiliation: School of Molecular Biosciences, University of Queensland, Brisbane, Queensland, Australia

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  • Rosemary Petric,

    Affiliation: Hoffmann-La Roche, Nutley, New Jersey, United States of America

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  • Van Vinh Chau Nguyen,

    Affiliation: Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam

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  • Jeremy Farrar,

    Affiliations: Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam, Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

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  • Bridget Wills

    Affiliations: Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam, Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

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  • Published: September 27, 2012
  • DOI: 10.1371/journal.pntd.0001752

About the Authors

Cameron P. Simmons, Marcel Wolbers, Minh Nguyet Nguyen, Jamie Whitehorn, Jeremy Farrar, Bridget Wills
Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
Cameron P. Simmons, Marcel Wolbers, Jeremy Farrar, Bridget Wills
Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
Van Vinh Chau Nguyen
Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
Rosemary Petric
Hoffmann-La Roche, Nutley, New Jersey, United States of America
Pei Yong Shi
Novartis Institute for Tropical Diseases, Biopolis Way, Singapore
Jamie Whitehorn
London School of Hygiene and Tropical Medicine, London, United Kingdom
Paul Young
School of Molecular Biosciences, University of Queensland, Brisbane, Queensland, Australia

Corresponding Author

Email: csimmons@oucru.org

Competing Interests

The authors have read the journal's policy and have the following conflicts. Rosemary Petric is an employee of Hoffmann-La Roche, USA. Pei-Yong Shi is an employee of the Novartis Institute of Tropical Diseases, Singapore. Cameron Simmons is a consultant to Unither Virology LLC. The corresponding author (CPS) takes responsibility for the content of this paper and the decision to submit for publication.