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Research Article

Whole Organism High-Content Screening by Label-Free, Image-Based Bayesian Classification for Parasitic Diseases

  • Ross A. Paveley,

    Affiliation: Department of Infection and Immunity, London School of Hygiene and Tropical Medicine, London, United Kingdom

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  • Nuha R. Mansour,

    Affiliation: Department of Infection and Immunity, London School of Hygiene and Tropical Medicine, London, United Kingdom

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  • Irene Hallyburton,

    Affiliation: Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, United Kingdom

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  • Leo S. Bleicher,

    Affiliation: Accelrys Inc., San Diego, California, United States of America

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  • Alex E. Benn,

    Affiliation: Accelrys Ltd, Cambridge, United Kingdom

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  • Ivana Mikic,

    Affiliation: Accelrys Inc., San Diego, California, United States of America

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  • Alessandra Guidi,

    Affiliation: Department of Infection and Immunity, London School of Hygiene and Tropical Medicine, London, United Kingdom

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  • Ian H. Gilbert,

    Affiliation: Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, United Kingdom

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  • Andrew L. Hopkins,

    Affiliation: Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, United Kingdom

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  • Quentin D. Bickle mail

    quentin.bickle@lshtm.ac.uk

    Affiliation: Department of Infection and Immunity, London School of Hygiene and Tropical Medicine, London, United Kingdom

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  • Published: July 31, 2012
  • DOI: 10.1371/journal.pntd.0001762

About the Authors

Ross A. Paveley, Nuha R. Mansour, Alessandra Guidi, Quentin D. Bickle
Department of Infection and Immunity, London School of Hygiene and Tropical Medicine, London, United Kingdom
Irene Hallyburton, Ian H. Gilbert, Andrew L. Hopkins
Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, United Kingdom
Leo S. Bleicher, Ivana Mikic
Accelrys Inc., San Diego, California, United States of America
Alex E. Benn
Accelrys Ltd, Cambridge, United Kingdom

Corresponding Author

Email: quentin.bickle@lshtm.ac.uk

Competing Interests

The authors have read the journal's policy and have the following conflicts: LSB, AEB and IM receive a salary from Accelrys, who markets Pipeline Pilot as commercial software, in which the authors designed their analysis protocols. This does not alter the authors' adherence to all PLoS Neglected Tropical Diseases policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: QDB ALH RAP. Performed the experiments: RAP NRM AG. Analyzed the data: RAP QDB NRM. Contributed reagents/materials/analysis tools: IHG IH LSB AEB IM. Wrote the paper: RAP QDB.