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Research Article

Transcriptomic Signature of Leishmania Infected Mice Macrophages: A Metabolic Point of View

  • Imen Rabhi equal contributor,

    equal contributor Contributed equally to this work with: Imen Rabhi, Sameh Rabhi

    Affiliation: Laboratory of Immunopathology, Vaccinology and Molecular Genetics (LIVGM), WHO Collaborating Center for Research and Training in Leishmaniasis and Laboratoire International Associé Ingenierie Biomoléculaire (LIA-CNRS), Institut Pasteur de Tunis, Tunis-Belvedere, Tunisia

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  • Sameh Rabhi equal contributor,

    equal contributor Contributed equally to this work with: Imen Rabhi, Sameh Rabhi

    Affiliation: Laboratory of Immunopathology, Vaccinology and Molecular Genetics (LIVGM), WHO Collaborating Center for Research and Training in Leishmaniasis and Laboratoire International Associé Ingenierie Biomoléculaire (LIA-CNRS), Institut Pasteur de Tunis, Tunis-Belvedere, Tunisia

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  • Rym Ben-Othman,

    Affiliation: Laboratory of Immunopathology, Vaccinology and Molecular Genetics (LIVGM), WHO Collaborating Center for Research and Training in Leishmaniasis and Laboratoire International Associé Ingenierie Biomoléculaire (LIA-CNRS), Institut Pasteur de Tunis, Tunis-Belvedere, Tunisia

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  • Axel Rasche,

    Affiliation: Department Lehrach (Vertebrate Genomics Department), Max-Planck-Institute for Molecular Genetics, Berlin, Germany

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  • Sysco Consortium,

    Membership of the Sysco Consortium is provided in the Acknowledgments.

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  • Adriani Daskalaki,

    Affiliation: Department Lehrach (Vertebrate Genomics Department), Max-Planck-Institute for Molecular Genetics, Berlin, Germany

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  • Bernadette Trentin,

    Affiliation: Skuldtech. Cap Delta - ZAC Euromedecine II, Grabels, France

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  • David Piquemal,

    Affiliation: Skuldtech. Cap Delta - ZAC Euromedecine II, Grabels, France

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  • Béatrice Regnault,

    Affiliation: Genopole, Institut Pasteur de Paris, Paris, France

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  • Albert Descoteaux,

    Affiliation: INRS-Institut Armand Frappier and Centre for Host-Parasite Interactions, Laval, Québec, Canada

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  • Lamia Guizani-Tabbane mail

    lamia.guizani@Pasteur.rns.tn

    Affiliation: Laboratory of Immunopathology, Vaccinology and Molecular Genetics (LIVGM), WHO Collaborating Center for Research and Training in Leishmaniasis and Laboratoire International Associé Ingenierie Biomoléculaire (LIA-CNRS), Institut Pasteur de Tunis, Tunis-Belvedere, Tunisia

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  • Published: August 21, 2012
  • DOI: 10.1371/journal.pntd.0001763

About the Authors

Imen Rabhi, Sameh Rabhi, Rym Ben-Othman, Lamia Guizani-Tabbane
Laboratory of Immunopathology, Vaccinology and Molecular Genetics (LIVGM), WHO Collaborating Center for Research and Training in Leishmaniasis and Laboratoire International Associé Ingenierie Biomoléculaire (LIA-CNRS), Institut Pasteur de Tunis, Tunis-Belvedere, Tunisia
Axel Rasche, Adriani Daskalaki
Department Lehrach (Vertebrate Genomics Department), Max-Planck-Institute for Molecular Genetics, Berlin, Germany
Bernadette Trentin, David Piquemal
Skuldtech. Cap Delta - ZAC Euromedecine II, Grabels, France
Béatrice Regnault
Genopole, Institut Pasteur de Paris, Paris, France
Albert Descoteaux
INRS-Institut Armand Frappier and Centre for Host-Parasite Interactions, Laval, Québec, Canada

Corresponding Author

Email: lamia.guizani@Pasteur.rns.tn

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LGT. Performed the experiments: IR SR RBO BT DP. Analyzed the data: IR SR AR A. Daskalaki BR BT DP A. Descoteaux LGT. Contributed reagents/materials/analysis tools: LGT A. Daskalaki BT DP BR A. Descoteaux. Wrote the paper: LGT A. Daskalaki IR SR BT. Manuscript correction: BT A. Descoteaux.