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Research Article

An Analytical Method for Assessing Stage-Specific Drug Activity in Plasmodium vivax Malaria: Implications for Ex Vivo Drug Susceptibility Testing

  • Douglas H. Kerlin,

    Affiliation: Malaria Drug Resistance and Chemotherapy Laboratory, Queensland Institute of Medical Research, Brisbane, Australia

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  • Kane Boyce,

    Affiliation: Malaria Drug Resistance and Chemotherapy Laboratory, Queensland Institute of Medical Research, Brisbane, Australia

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  • Jutta Marfurt,

    Affiliation: Menzies School of Health Research and Charles Darwin University, Darwin, Australia

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  • Julie A. Simpson,

    Affiliation: Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Melbourne, Australia

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  • Enny Kenangalem,

    Affiliations: Papuan Health and Community Development Foundation (PHCDF), Timika, Papua, Indonesia, District Health Authority and the Menzies School of Health Research-National Institute of Health Research and Development, Timika, Papua, Indonesia, District Ministry of Health, Timika, Papua, Indonesia

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  • Qin Cheng,

    Affiliation: Department of Drug Resistance and Diagnostics, Australian Army Malaria Institute, Brisbane, Australia

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  • Ric N. Price,

    Affiliations: Menzies School of Health Research and Charles Darwin University, Darwin, Australia, Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom

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  • Michelle L. Gatton mail

    Michelle.Gatton@qimr.edu.au

    Affiliation: Malaria Drug Resistance and Chemotherapy Laboratory, Queensland Institute of Medical Research, Brisbane, Australia

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  • Published: August 07, 2012
  • DOI: 10.1371/journal.pntd.0001772

About the Authors

Douglas H. Kerlin, Kane Boyce, Michelle L. Gatton
Malaria Drug Resistance and Chemotherapy Laboratory, Queensland Institute of Medical Research, Brisbane, Australia
Jutta Marfurt, Ric N. Price
Menzies School of Health Research and Charles Darwin University, Darwin, Australia
Julie A. Simpson
Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Melbourne, Australia
Enny Kenangalem
Papuan Health and Community Development Foundation (PHCDF), Timika, Papua, Indonesia
Enny Kenangalem
District Health Authority and the Menzies School of Health Research-National Institute of Health Research and Development, Timika, Papua, Indonesia
Enny Kenangalem
District Ministry of Health, Timika, Papua, Indonesia
Qin Cheng
Department of Drug Resistance and Diagnostics, Australian Army Malaria Institute, Brisbane, Australia
Ric N. Price
Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom

Corresponding Author

Email: Michelle.Gatton@qimr.edu.au

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DHK QC RNP MLG. Performed the experiments: JM DHK KB JAS EK. Analyzed the data: DHK KB JAS. Wrote the paper: DHK QC RNP MLG.