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Research Article

Whole Genome Sequencing of Field Isolates Provides Robust Characterization of Genetic Diversity in Plasmodium vivax

  • Ernest R. Chan equal contributor,

    equal contributor Contributed equally to this work with: Ernest R. Chan, Didier Menard

    Affiliation: Genomic Medicine Institute, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio, United States of America

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  • Didier Menard equal contributor mail,

    equal contributor Contributed equally to this work with: Ernest R. Chan, Didier Menard

    dmenard@pasteur-kh.org (DM); omp@pasteur.fr (OM-P); paz@case.edu (PAZ); serred@ccf.org (DS)

    Affiliation: Unité d'Epidémiologie Moléculaire, Institut Pasteur du Cambodge, Phnom Penh, Cambodia

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  • Peter H. David,

    Affiliation: Unité d'lmmunologie Moléculaire des Parasites, Institut Pasteur, Paris, France

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  • Arsène Ratsimbasoa,

    Affiliation: Direction de la lute contre les maladies infectieuses, Ministère de la santé, du planning familial et de la protection sociale, Antananarivo, Madagascar

    X
  • Saorin Kim,

    Affiliation: Unité d'Epidémiologie Moléculaire, Institut Pasteur du Cambodge, Phnom Penh, Cambodia

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  • Pheaktra Chim,

    Affiliation: Unité d'Epidémiologie Moléculaire, Institut Pasteur du Cambodge, Phnom Penh, Cambodia

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  • Catherine Do,

    Affiliation: Unité d'Epidémiologie Moléculaire, Institut Pasteur du Cambodge, Phnom Penh, Cambodia

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  • Benoit Witkowski,

    Affiliation: Unité d'Epidémiologie Moléculaire, Institut Pasteur du Cambodge, Phnom Penh, Cambodia

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  • Odile Mercereau-Puijalon mail,

    dmenard@pasteur-kh.org (DM); omp@pasteur.fr (OM-P); paz@case.edu (PAZ); serred@ccf.org (DS)

    Affiliation: Unité d'lmmunologie Moléculaire des Parasites, Institut Pasteur, Paris, France

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  • Peter A. Zimmerman mail,

    dmenard@pasteur-kh.org (DM); omp@pasteur.fr (OM-P); paz@case.edu (PAZ); serred@ccf.org (DS)

    Affiliation: Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio, United States of America

    These authors also contributed equally to this work.

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  • David Serre mail

    dmenard@pasteur-kh.org (DM); omp@pasteur.fr (OM-P); paz@case.edu (PAZ); serred@ccf.org (DS)

    Affiliation: Genomic Medicine Institute, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio, United States of America

    These authors also contributed equally to this work.

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  • Published: September 06, 2012
  • DOI: 10.1371/journal.pntd.0001811

About the Authors

Ernest R. Chan, David Serre
Genomic Medicine Institute, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio, United States of America
Didier Menard, Saorin Kim, Pheaktra Chim, Catherine Do, Benoit Witkowski
Unité d'Epidémiologie Moléculaire, Institut Pasteur du Cambodge, Phnom Penh, Cambodia
Peter H. David, Odile Mercereau-Puijalon
Unité d'lmmunologie Moléculaire des Parasites, Institut Pasteur, Paris, France
Arsène Ratsimbasoa
Direction de la lute contre les maladies infectieuses, Ministère de la santé, du planning familial et de la protection sociale, Antananarivo, Madagascar
Peter A. Zimmerman
Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PAZ DS. Performed the experiments: ERC DM PHD AR SK PC CD BW. Analyzed the data: ERC DM PAZ DS. Contributed reagents/materials/analysis tools: ERC DM PHD AR SK PC CD BW OMP PAZ DS. Wrote the paper: ERC DM OMP PAZ DS.