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Research Article

Transcriptome Patterns from Primary Cutaneous Leishmania braziliensis Infections Associate with Eventual Development of Mucosal Disease in Humans

  • Ana Claudia Maretti-Mira,

    Affiliations: Division of Molecular Medicine, Department of Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, United States of America, Laboratório Interdisciplinar de Pesquisas Médicas, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, Rio de Janeiro, Brazil

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  • Jaime Bittner,

    Affiliation: Division of Molecular Medicine, Department of Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, United States of America

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  • Manoel Paes Oliveira-Neto,

    Affiliation: Ambulatório de Leishmanioses, Instituto de Pesquisas Clínicas Evandro Chagas, Fiocruz, Rio de Janeiro, Rio de Janeiro, Brazil

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  • Minghsun Liu,

    Affiliations: Infectious Diseases Section (111 F) and Research Service, VA Medical Center West Los Angeles, Los Angeles, California, United States of America, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

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  • Dezhi Kang,

    Affiliations: David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America, Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging, UCLA-DOE Institute for Genomics and Proteomics, Los Angeles, California, United States of America

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  • Huiying Li,

    Affiliations: David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America, Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging, UCLA-DOE Institute for Genomics and Proteomics, Los Angeles, California, United States of America

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  • Claude Pirmez,

    Affiliation: Laboratório Interdisciplinar de Pesquisas Médicas, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, Rio de Janeiro, Brazil

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  • Noah Craft mail

    ncraft@ucla.edu

    Affiliations: Division of Molecular Medicine, Department of Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, United States of America, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

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  • Published: September 13, 2012
  • DOI: 10.1371/journal.pntd.0001816

About the Authors

Ana Claudia Maretti-Mira, Jaime Bittner, Noah Craft
Division of Molecular Medicine, Department of Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, United States of America
Ana Claudia Maretti-Mira, Claude Pirmez
Laboratório Interdisciplinar de Pesquisas Médicas, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, Rio de Janeiro, Brazil
Manoel Paes Oliveira-Neto
Ambulatório de Leishmanioses, Instituto de Pesquisas Clínicas Evandro Chagas, Fiocruz, Rio de Janeiro, Rio de Janeiro, Brazil
Minghsun Liu
Infectious Diseases Section (111 F) and Research Service, VA Medical Center West Los Angeles, Los Angeles, California, United States of America
Minghsun Liu, Dezhi Kang, Huiying Li, Noah Craft
David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
Dezhi Kang, Huiying Li
Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging, UCLA-DOE Institute for Genomics and Proteomics, Los Angeles, California, United States of America

Corresponding Author

Email: ncraft@ucla.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ACMM JB MPON ML DK HL CP NC. Performed the experiments: ACMM. Analyzed the data: ACMM JB MPON ML DK HL CP NC. Contributed reagents/materials/analysis tools: ACMM JB MPON ML DK HL CP NC. Wrote the paper: ACMM DK HL CP NC.