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Research Article

G Protein-Coupled Receptor Kinase 2 Promotes Flaviviridae Entry and Replication

  • Caroline Le Sommer,

    Affiliations: Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America, Center for RNA Biology, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Nicholas J. Barrows,

    Affiliations: Center for RNA Biology, Duke University Medical Center, Durham, North Carolina, United States of America, Duke RNAi Screening Facility, Duke University Medical Center, Durham, North Carolina, United States of America, Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, United States of America

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  • Shelton S. Bradrick,

    Affiliations: Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America, Center for RNA Biology, Duke University Medical Center, Durham, North Carolina, United States of America

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  • James L. Pearson,

    Affiliations: Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America, Center for RNA Biology, Duke University Medical Center, Durham, North Carolina, United States of America, Duke RNAi Screening Facility, Duke University Medical Center, Durham, North Carolina, United States of America

    X
  • Mariano A. Garcia-Blanco mail

    m.garciablanco@duke.edu

    Affiliations: Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America, Center for RNA Biology, Duke University Medical Center, Durham, North Carolina, United States of America, Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America, Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, Singapore, Republic of Singapore

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  • Published: September 13, 2012
  • DOI: 10.1371/journal.pntd.0001820

About the Authors

Caroline Le Sommer, Shelton S. Bradrick, James L. Pearson, Mariano A. Garcia-Blanco
Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America
Caroline Le Sommer, Nicholas J. Barrows, Shelton S. Bradrick, James L. Pearson, Mariano A. Garcia-Blanco
Center for RNA Biology, Duke University Medical Center, Durham, North Carolina, United States of America
Nicholas J. Barrows, James L. Pearson
Duke RNAi Screening Facility, Duke University Medical Center, Durham, North Carolina, United States of America
Nicholas J. Barrows
Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, United States of America
Mariano A. Garcia-Blanco
Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America
Mariano A. Garcia-Blanco
Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, Singapore, Republic of Singapore

Corresponding Author

Email: m.garciablanco@duke.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CLS NJB SSB JLP MAGB. Performed the experiments: CLS NJB SSB JLP. Analyzed the data: CLS NJB SSB JLP MAGB. Wrote the paper: CLS NJB SSB JLP MAGB.