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Research Article

Impact of Amino Acid Substitutions in B Subunit of DNA Gyrase in Mycobacterium leprae on Fluoroquinolone Resistance

  • Kazumasa Yokoyama,

    Affiliation: Division of Global Epidemiology, Hokkaido University Research Center for Zoonosis Control, Sapporo, Hokkaido, Japan

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  • Hyun Kim,

    Affiliation: Division of Global Epidemiology, Hokkaido University Research Center for Zoonosis Control, Sapporo, Hokkaido, Japan

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  • Tetsu Mukai,

    Affiliation: Leprosy Research Center, National Institute of Infectious Diseases, Higashimurayama, Tokyo, Japan

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  • Masanori Matsuoka,

    Affiliation: Leprosy Research Center, National Institute of Infectious Diseases, Higashimurayama, Tokyo, Japan

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  • Chie Nakajima,

    Affiliation: Division of Global Epidemiology, Hokkaido University Research Center for Zoonosis Control, Sapporo, Hokkaido, Japan

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  • Yasuhiko Suzuki mail

    suzuki@czc.hokudai.ac.jp

    Affiliations: Division of Global Epidemiology, Hokkaido University Research Center for Zoonosis Control, Sapporo, Hokkaido, Japan, JST/JICA-SATREPS, Tokyo, Japan

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  • Published: October 11, 2012
  • DOI: 10.1371/journal.pntd.0001838

About the Authors

Kazumasa Yokoyama, Hyun Kim, Chie Nakajima, Yasuhiko Suzuki
Division of Global Epidemiology, Hokkaido University Research Center for Zoonosis Control, Sapporo, Hokkaido, Japan
Tetsu Mukai, Masanori Matsuoka
Leprosy Research Center, National Institute of Infectious Diseases, Higashimurayama, Tokyo, Japan
Yasuhiko Suzuki
JST/JICA-SATREPS, Tokyo, Japan

Corresponding Author

Email: suzuki@czc.hokudai.ac.jp

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TM MM CN YS. Performed the experiments: KY HK CN. Analyzed the data: KY CN YS. Contributed reagents/materials/analysis tools: KY TM MM. Wrote the paper: KY TM MM CN YS.