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Research Article

Serum Proteome and Cytokine Analysis in a Longitudinal Cohort of Adults with Primary Dengue Infection Reveals Predictive Markers of DHF

  • Yadunanda Kumar mail,

    ybudigi@mit.edu

    Affiliations: Interdisciplinary Research Group in Infectious diseases, Singapore-MIT Alliance for Research and Technology (SMART), Singapore, Singapore, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Cui Liang,

    Affiliation: Interdisciplinary Research Group in Infectious diseases, Singapore-MIT Alliance for Research and Technology (SMART), Singapore, Singapore

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  • Zheng Bo,

    Affiliation: School of Computer Engineering, Nanyang Technological University (NTU), Singapore, Singapore

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  • Jagath C. Rajapakse,

    Affiliation: School of Computer Engineering, Nanyang Technological University (NTU), Singapore, Singapore

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  • Eng Eong Ooi,

    Affiliation: DUKE-NUS Graduate Medical School, Singapore, Singapore

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  • Steven R. Tannenbaum

    Affiliations: Interdisciplinary Research Group in Infectious diseases, Singapore-MIT Alliance for Research and Technology (SMART), Singapore, Singapore, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Published: November 29, 2012
  • DOI: 10.1371/journal.pntd.0001887

About the Authors

Yadunanda Kumar, Cui Liang, Steven R. Tannenbaum
Interdisciplinary Research Group in Infectious diseases, Singapore-MIT Alliance for Research and Technology (SMART), Singapore, Singapore
Yadunanda Kumar, Steven R. Tannenbaum
Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
Zheng Bo, Jagath C. Rajapakse
School of Computer Engineering, Nanyang Technological University (NTU), Singapore, Singapore
Eng Eong Ooi
DUKE-NUS Graduate Medical School, Singapore, Singapore

Corresponding Author

Email: ybudigi@mit.edu

Competing Interests

Yadunanda Kumar, Steven Tannenbaum, EngEong Ooi and Jagath Rajapakse have applied for a patent on some of the markers identified in the study. This does not alter the authors' adherence to all the PLOS policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: SRT YK EEO. Performed the experiments: YK CL ZB. Analyzed the data: YK ZB JCR SRT EEO. Contributed reagents/materials/analysis tools: ZB JCR EEO. Wrote the paper: YK SRT EEO JCR.