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Research Article

A Transcriptomic Analysis of Echinococcus granulosus Larval Stages: Implications for Parasite Biology and Host Adaptation

  • John Parkinson,

    Affiliation: Program in Molecular Structure and Function, Hospital for Sick Children, University of Toronto, Toronto, Canada

    Current address: Instituto Nacional de Ciência e Tecnologia em Tuberculose, Centro de Pesquisas em Biologia Molecular e Funcional, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil

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  • James D. Wasmuth,

    Affiliation: Program in Molecular Structure and Function, Hospital for Sick Children, University of Toronto, Toronto, Canada

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  • Gustavo Salinas,

    Affiliation: Cátedra de Inmunología, Facultad de Química, Universidad de la República, Montevideo, Uruguay

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  • Cristiano V. Bizarro,

    Affiliation: Laboratório de Biologia Molecular de Cestódeos and Laboratorio de Genômica Estrutural e Funcional, Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

    Current address: Instituto Nacional de Ciência e Tecnologia em Tuberculose, Centro de Pesquisas em Biologia Molecular e Funcional, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil

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  • Chris Sanford,

    Affiliation: Program in Molecular Structure and Function, Hospital for Sick Children, University of Toronto, Toronto, Canada

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  • Matthew Berriman,

    Affiliation: Parasite Genomics, The Wellcome Trust Sanger Institute, Hinxton, United Kingdom

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  • Henrique B. Ferreira,

    Affiliation: Laboratório de Biologia Molecular de Cestódeos and Laboratorio de Genômica Estrutural e Funcional, Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

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  • Arnaldo Zaha,

    Affiliation: Laboratório de Biologia Molecular de Cestódeos and Laboratorio de Genômica Estrutural e Funcional, Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

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  • Mark L. Blaxter,

    Affiliation: Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom

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  • Rick M. Maizels mail,

    rick.maizels@ed.ac.uk (RMM); cfernan@fq.edu.uy (CF)

    Affiliation: Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom

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  • Cecilia Fernández mail

    rick.maizels@ed.ac.uk (RMM); cfernan@fq.edu.uy (CF)

    Affiliation: Cátedra de Inmunología, Facultad de Química, Universidad de la República, Montevideo, Uruguay

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  • Published: November 29, 2012
  • DOI: 10.1371/journal.pntd.0001897

About the Authors

John Parkinson, James D. Wasmuth, Chris Sanford
Program in Molecular Structure and Function, Hospital for Sick Children, University of Toronto, Toronto, Canada
Gustavo Salinas, Cecilia Fernández
Cátedra de Inmunología, Facultad de Química, Universidad de la República, Montevideo, Uruguay
Cristiano V. Bizarro, Henrique B. Ferreira, Arnaldo Zaha
Laboratório de Biologia Molecular de Cestódeos and Laboratorio de Genômica Estrutural e Funcional, Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
Matthew Berriman
Parasite Genomics, The Wellcome Trust Sanger Institute, Hinxton, United Kingdom
Mark L. Blaxter
Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
Rick M. Maizels
Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RMM CF. Performed the experiments: JP JDW CVB CS CF. Analyzed the data: JP JDW GS MLB RMM CF. Contributed reagents/materials/analysis tools: MB HBF AZ. Wrote the paper: JP GS CF. Prepared tables and figures: JP JDW GS CF.