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Research Article

Affinity Is an Important Determinant of the Anti-Trypanosome Activity of Nanobodies

  • Guy Caljon mail,

    gcaljon@itg.be

    Affiliations: Department of Biomedical Sciences, Unit of Veterinary Protozoology, Institute of Tropical Medicine Antwerp, Antwerp, Belgium, Research Unit of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium, Laboratory of Myeloid Cell Immunology, VIB, Brussels, Belgium

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  • Benoît Stijlemans,

    Affiliations: Research Unit of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium, Laboratory of Myeloid Cell Immunology, VIB, Brussels, Belgium

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  • Dirk Saerens,

    Affiliations: Research Unit of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium, Department of Structural Biology, VIB, Brussels, Belgium

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  • Jan Van Den Abbeele,

    Affiliation: Department of Biomedical Sciences, Unit of Veterinary Protozoology, Institute of Tropical Medicine Antwerp, Antwerp, Belgium

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  • Serge Muyldermans,

    Affiliations: Research Unit of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium, Department of Structural Biology, VIB, Brussels, Belgium

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  • Stefan Magez,

    Affiliations: Research Unit of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium, Department of Structural Biology, VIB, Brussels, Belgium

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  • Patrick De Baetselier

    Affiliations: Research Unit of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium, Laboratory of Myeloid Cell Immunology, VIB, Brussels, Belgium

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  • Published: November 15, 2012
  • DOI: 10.1371/journal.pntd.0001902

About the Authors

Guy Caljon, Jan Van Den Abbeele
Department of Biomedical Sciences, Unit of Veterinary Protozoology, Institute of Tropical Medicine Antwerp, Antwerp, Belgium
Guy Caljon, Benoît Stijlemans, Dirk Saerens, Serge Muyldermans, Stefan Magez, Patrick De Baetselier
Research Unit of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium
Guy Caljon, Benoît Stijlemans, Patrick De Baetselier
Laboratory of Myeloid Cell Immunology, VIB, Brussels, Belgium
Dirk Saerens, Serge Muyldermans, Stefan Magez
Department of Structural Biology, VIB, Brussels, Belgium

Corresponding Author

Email: gcaljon@itg.be

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GC DS S. Muyldermans S. Magez PDB. Performed the experiments: GC BS. Analyzed the data: GC BS S. Muyldermans. Contributed reagents/materials/analysis tools: GC JVDA S. Magez PDB. Wrote the paper: GC BS DS JVDA S. Muyldermans S. Magez PDB.