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Research Article

Corticosteroid-Induced Immunosuppression Ultimately Does Not Compromise the Efficacy of Antibiotherapy in Murine Mycobacterium ulcerans Infection

  • Teresa G. Martins,

    Affiliations: Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, Braga, Portugal, ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal

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  • Gabriela Trigo,

    Affiliations: Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, Braga, Portugal, ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal, Institute for Biotechnology and Bioengineering, Centre of Biological Engineering, University of Minho, Braga, Portugal

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  • Alexandra G. Fraga,

    Affiliations: Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, Braga, Portugal, ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal

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  • José B. Gama,

    Affiliations: Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, Braga, Portugal, ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal

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  • Adhemar Longatto-Filho,

    Affiliations: Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, Braga, Portugal, ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal, Laboratory of Medical Investigation 14, Faculty of Medicine of University of São Paulo, São Paulo, Brazil, Molecular Oncology Research Center, Barretos, São Paulo, Brazil

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  • Margarida Saraiva,

    Affiliations: Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, Braga, Portugal, ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal

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  • Manuel T. Silva †,

    † Deceased.

    Affiliation: Institute for Molecular and Cell Biology, Porto, Portugal

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  • António G. Castro,

    Affiliations: Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, Braga, Portugal, ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal

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  • Jorge Pedrosa mail

    jpedrosa@ecsaude.uminho.pt

    Affiliations: Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, Braga, Portugal, ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal

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  • Published: November 29, 2012
  • DOI: 10.1371/journal.pntd.0001925

About the Authors

Teresa G. Martins, Gabriela Trigo, Alexandra G. Fraga, José B. Gama, Adhemar Longatto-Filho, Margarida Saraiva, António G. Castro, Jorge Pedrosa
Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, Braga, Portugal
Teresa G. Martins, Gabriela Trigo, Alexandra G. Fraga, José B. Gama, Adhemar Longatto-Filho, Margarida Saraiva, António G. Castro, Jorge Pedrosa
ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal
Gabriela Trigo
Institute for Biotechnology and Bioengineering, Centre of Biological Engineering, University of Minho, Braga, Portugal
Adhemar Longatto-Filho
Laboratory of Medical Investigation 14, Faculty of Medicine of University of São Paulo, São Paulo, Brazil
Adhemar Longatto-Filho
Molecular Oncology Research Center, Barretos, São Paulo, Brazil
Manuel T. Silva
Institute for Molecular and Cell Biology, Porto, Portugal

Corresponding Author

Email: jpedrosa@ecsaude.uminho.pt

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TGM MS MTS AGC JP. Performed the experiments: TGM GT AGF JBG ALF. Analyzed the data: TGM ALF MS MTS AGC JP. Contributed reagents/materials/analysis tools: TGM MS MTS AGC JP. Wrote the paper: TGM AGF ALF MS MTS AGC JP.