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Research Article

Appraisal of a Leishmania major Strain Stably Expressing mCherry Fluorescent Protein for Both In Vitro and In Vivo Studies of Potential Drugs and Vaccine against Cutaneous Leishmaniasis

  • Estefania Calvo-Álvarez equal contributor,

    equal contributor Contributed equally to this work with: Estefania Calvo-Álvarez, Nestor Adrian Guerrero

    Affiliation: Departamento de Ciencias Biomédicas, Universidad de León, León, Spain

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  • Nestor Adrian Guerrero equal contributor,

    equal contributor Contributed equally to this work with: Estefania Calvo-Álvarez, Nestor Adrian Guerrero

    Affiliation: Centro de Biología Molecular “Severo Ochoa”, Universidad Autónoma de Madrid, Madrid, Spain

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  • Raquel Álvarez-Velilla,

    Affiliation: Departamento de Ciencias Biomédicas, Universidad de León, León, Spain

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  • Christopher Fernández Prada,

    Affiliation: Departamento de Ciencias Biomédicas, Universidad de León, León, Spain

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  • Jose María Requena,

    Affiliation: Centro de Biología Molecular “Severo Ochoa”, Universidad Autónoma de Madrid, Madrid, Spain

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  • Carmen Punzón,

    Affiliation: Diomune, Parque Cientifico de Madrid, Madrid, Spain

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  • Miguel Ángel Llamas,

    Affiliation: Diomune, Parque Cientifico de Madrid, Madrid, Spain

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  • Francisco J. Arévalo,

    Affiliation: Diomune, Parque Cientifico de Madrid, Madrid, Spain

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  • Luis Rivas,

    Affiliation: Centro de Investigaciones Biológicas, Madrid, Spain

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  • Manuel Fresno,

    Affiliations: Centro de Biología Molecular “Severo Ochoa”, Universidad Autónoma de Madrid, Madrid, Spain, Diomune, Parque Cientifico de Madrid, Madrid, Spain

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  • Yolanda Pérez-Pertejo,

    Affiliation: Departamento de Ciencias Biomédicas, Universidad de León, León, Spain

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  • Rafael Balaña-Fouce mail,

    rbalf@unileon.es

    Affiliation: Departamento de Ciencias Biomédicas, Universidad de León, León, Spain

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  • Rosa M. Reguera

    Affiliation: Departamento de Ciencias Biomédicas, Universidad de León, León, Spain

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  • Published: November 29, 2012
  • DOI: 10.1371/journal.pntd.0001927

About the Authors

Estefania Calvo-Álvarez, Raquel Álvarez-Velilla, Christopher Fernández Prada, Yolanda Pérez-Pertejo, Rafael Balaña-Fouce, Rosa M. Reguera
Departamento de Ciencias Biomédicas, Universidad de León, León, Spain
Nestor Adrian Guerrero, Jose María Requena, Manuel Fresno
Centro de Biología Molecular “Severo Ochoa”, Universidad Autónoma de Madrid, Madrid, Spain
Carmen Punzón, Miguel Ángel Llamas, Francisco J. Arévalo, Manuel Fresno
Diomune, Parque Cientifico de Madrid, Madrid, Spain
Luis Rivas
Centro de Investigaciones Biológicas, Madrid, Spain

Corresponding Author

Email: rbalf@unileon.es

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RMR MF LR JMR. Performed the experiments: ECA NAG RAV CFP CP MAL FJA. Analyzed the data: ECA NAG YPP RMR JMR. Contributed reagents/materials/analysis tools: LR RBF RMR MF. Wrote the paper: RMR RBF JMR.