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Research Article

Deletion of Parasite Immune Modulatory Sequences Combined with Immune Activating Signals Enhances Vaccine Mediated Protection against Filarial Nematodes

  • Simon A. Babayan mail,

    s.babayan@ed.ac.uk

    Affiliations: Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh, United Kingdom, Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, United Kingdom

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  • HongLin Luo,

    Affiliation: Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, United Kingdom

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  • Nick Gray,

    Affiliation: Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, United Kingdom

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  • David W. Taylor,

    Affiliations: Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, United Kingdom, Division of Pathway Medicine, School for Biomedical Studies, University of Edinburgh, Edinburgh, United Kingdom

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  • Judith E. Allen

    Affiliations: Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh, United Kingdom, Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, United Kingdom

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  • Published: December 27, 2012
  • DOI: 10.1371/journal.pntd.0001968

About the Authors

Simon A. Babayan, Judith E. Allen
Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh, United Kingdom
Simon A. Babayan, HongLin Luo, Nick Gray, David W. Taylor, Judith E. Allen
Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, United Kingdom
David W. Taylor
Division of Pathway Medicine, School for Biomedical Studies, University of Edinburgh, Edinburgh, United Kingdom

Corresponding Author

Email: s.babayan@ed.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SAB JEA. Performed the experiments: HLL SAB NG. Analyzed the data: SAB. Wrote the paper: SAB DWT JEA.