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Research Article

Rapid and Scalable Plant-based Production of a Cholera Toxin B Subunit Variant to Aid in Mass Vaccination against Cholera Outbreaks

  • Krystal Teasley Hamorsky equal contributor,

    equal contributor Contributed equally to this work with: Krystal Teasley Hamorsky, J. Calvin Kouokam

    Affiliations: Owensboro Cancer Research Program, Owensboro, Kentucky, United States of America, Department of Pharmacology and Toxicology and James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky, United States of America

    X
  • J. Calvin Kouokam equal contributor,

    equal contributor Contributed equally to this work with: Krystal Teasley Hamorsky, J. Calvin Kouokam

    Affiliations: Owensboro Cancer Research Program, Owensboro, Kentucky, United States of America, Department of Pharmacology and Toxicology and James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky, United States of America

    X
  • Lauren J. Bennett,

    Affiliation: Owensboro Cancer Research Program, Owensboro, Kentucky, United States of America

    X
  • Keegan J. Baldauf,

    Affiliation: Department of Pharmacology and Toxicology and James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky, United States of America

    X
  • Hiroyuki Kajiura,

    Affiliation: International Center for Biotechnology, Osaka University, Osaka, Japan

    X
  • Kazuhito Fujiyama,

    Affiliation: International Center for Biotechnology, Osaka University, Osaka, Japan

    X
  • Nobuyuki Matoba mail

    n.matoba@louisville.edu

    Affiliations: Owensboro Cancer Research Program, Owensboro, Kentucky, United States of America, Department of Pharmacology and Toxicology and James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky, United States of America

    X
  • Published: March 07, 2013
  • DOI: 10.1371/journal.pntd.0002046

About the Authors

Krystal Teasley Hamorsky, J. Calvin Kouokam, Lauren J. Bennett, Nobuyuki Matoba
Owensboro Cancer Research Program, Owensboro, Kentucky, United States of America
Krystal Teasley Hamorsky, J. Calvin Kouokam, Keegan J. Baldauf, Nobuyuki Matoba
Department of Pharmacology and Toxicology and James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky, United States of America
Hiroyuki Kajiura, Kazuhito Fujiyama
International Center for Biotechnology, Osaka University, Osaka, Japan

Corresponding Author

Email: n.matoba@louisville.edu

Competing Interests

I have read the journal's policy and have the following conflicts: KTH and NM have filed a patent application concerning the findings described in this paper (International Patent Application No. PCT/US12/29072).

Author Contributions

Conceived and designed the experiments: NM. Performed the experiments: KTH JCK LJB KJB HK. Analyzed the data: KTH JCK HK KF NM. Contributed reagents/materials/analysis tools: KF. Wrote the paper: KTH JCK NM.