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Research Article

Dissecting the Active Site of the Collagenolytic Cathepsin L3 Protease of the Invasive Stage of Fasciola hepatica

  • Ileana Corvo,

    Affiliation: Departamento de Genética, Facultad de Medicina, Universidad de la República, UDELAR, Montevideo, Uruguay

    X
  • Anthony J. O'Donoghue,

    Affiliation: Department of Pharmaceutical Chemistry, Pharmacology, and Biochemistry and Biophysics, University of California, San Francisco, California, United States of America

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  • Lucía Pastro,

    Affiliations: Departamento de Genética, Facultad de Medicina, Universidad de la República, UDELAR, Montevideo, Uruguay, Laboratorio de Interacciones Moleculares, Facultad de Ciencias, Universidad de la República, UDELAR, Montevideo, Uruguay

    X
  • Natalia Pi-Denis,

    Affiliation: Departamento de Genética, Facultad de Medicina, Universidad de la República, UDELAR, Montevideo, Uruguay

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  • Alegra Eroy-Reveles,

    Affiliation: Department of Chemistry and Biochemistry, San Francisco State University, San Francisco, California, United States of America

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  • Leda Roche,

    Affiliation: Departamento de Genética, Facultad de Medicina, Universidad de la República, UDELAR, Montevideo, Uruguay

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  • James H. McKerrow,

    Affiliation: Center for Discovery and Innovation in Parasitic Diseases, Department of Pathology, University of California, San Francisco, California, United States of America

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  • John P. Dalton,

    Affiliation: Institute of Parasitology, McGill University, Quebec, Canada

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  • Charles S. Craik,

    Affiliation: Department of Pharmaceutical Chemistry, Pharmacology, and Biochemistry and Biophysics, University of California, San Francisco, California, United States of America

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  • Conor R. Caffrey,

    Affiliation: Center for Discovery and Innovation in Parasitic Diseases, Department of Pathology, University of California, San Francisco, California, United States of America

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  • José F. Tort mail

    jtort@fmed.edu.uy

    Affiliation: Departamento de Genética, Facultad de Medicina, Universidad de la República, UDELAR, Montevideo, Uruguay

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  • Published: July 11, 2013
  • DOI: 10.1371/journal.pntd.0002269

About the Authors

Ileana Corvo, Lucía Pastro, Natalia Pi-Denis, Leda Roche, José F. Tort
Departamento de Genética, Facultad de Medicina, Universidad de la República, UDELAR, Montevideo, Uruguay
Anthony J. O'Donoghue, Charles S. Craik
Department of Pharmaceutical Chemistry, Pharmacology, and Biochemistry and Biophysics, University of California, San Francisco, California, United States of America
Lucía Pastro
Laboratorio de Interacciones Moleculares, Facultad de Ciencias, Universidad de la República, UDELAR, Montevideo, Uruguay
Alegra Eroy-Reveles
Department of Chemistry and Biochemistry, San Francisco State University, San Francisco, California, United States of America
James H. McKerrow, Conor R. Caffrey
Center for Discovery and Innovation in Parasitic Diseases, Department of Pathology, University of California, San Francisco, California, United States of America
John P. Dalton
Institute of Parasitology, McGill University, Quebec, Canada

Corresponding Author

Email: jtort@fmed.edu.uy

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: IC LR CRC JFT. Performed the experiments: IC AJOD LP NPD. Analyzed the data: IC AJOD LP CRC JPD JFT. Contributed reagents/materials/analysis tools: AER JHM CSC. Wrote the paper: IC AJOD CRC JPD JFT.