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Research Article

Transcriptomic Profiling of Diverse Aedes aegypti Strains Reveals Increased Basal-level Immune Activation in Dengue Virus-refractory Populations and Identifies Novel Virus-vector Molecular Interactions

  • Shuzhen Sim,

    Affiliation: W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America

    Current address: Genome Institute of Singapore, Singapore, Singapore

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  • Natapong Jupatanakul,

    Affiliation: W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America

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  • José L. Ramirez,

    Affiliation: W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America

    Current address: Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America

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  • Seokyoung Kang,

    Affiliation: W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America

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  • Claudia M. Romero-Vivas,

    Affiliation: Laboratorio de Enfermedades Tropicales, Departamento de Medicina, Fundación Universidad del Norte, Barranquilla, Colombia

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  • Hamish Mohammed,

    Affiliation: Health Sciences, University of Trinidad and Tobago, O'Meara Campus, Arima, Trinidad and Tobago

    Current address: HIV & STI Department, Health Protection Agency, London, United Kingdom

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  • George Dimopoulos mail

    gdimopou@jhsph.edu

    Affiliation: W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America

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  • Published: July 04, 2013
  • DOI: 10.1371/journal.pntd.0002295

About the Authors

Shuzhen Sim, Natapong Jupatanakul, José L. Ramirez, Seokyoung Kang, George Dimopoulos
W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America
Claudia M. Romero-Vivas
Laboratorio de Enfermedades Tropicales, Departamento de Medicina, Fundación Universidad del Norte, Barranquilla, Colombia
Hamish Mohammed
Health Sciences, University of Trinidad and Tobago, O'Meara Campus, Arima, Trinidad and Tobago

Corresponding Author

Email: gdimopou@jhsph.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SS JLR GD. Performed the experiments: SS NJ JLR SK CMRV HM. Analyzed the data: SS NJ JLR SK GD. Contributed reagents/materials/analysis tools: SS NJ JLR CMRV HM GD. Wrote the paper: SS GD.