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Research Article

Sequential Waves of Gene Expression in Patients with Clinically Defined Dengue Illnesses Reveal Subtle Disease Phases and Predict Disease Severity

  • Peifang Sun mail,

    peifang.sun@med.navy.mil

    Affiliations: Naval Medical Research Center, Silver Spring, Maryland, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland, United States of America

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  • Josefina García,

    Affiliation: US Naval Medical Research Unit No. 6, Lima, Peru

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  • Guillermo Comach,

    Affiliation: Laboratorio Regional de Diagnóstico e Investigación del Dengue y otras Enfermedades Virales (LARDIDEV), Instituto de Investigaciones Biomédicas de la Universidad de Carabobo (BIOMED-UC), Maracay, Venezuela

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  • Maryanne T. Vahey,

    Affiliation: Division of Retrovirology, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America

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  • Zhining Wang,

    Affiliation: Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland, United States of America

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  • Brett M. Forshey,

    Affiliation: US Naval Medical Research Unit No. 6, Lima, Peru

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  • Amy C. Morrison,

    Affiliations: US Naval Medical Research Unit No. 6, Lima, Peru, Department of Entomology, University of California at Davis, Davis, California, United States of America

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  • Gloria Sierra,

    Affiliation: Laboratorio Regional de Diagnóstico e Investigación del Dengue y otras Enfermedades Virales (LARDIDEV), Instituto de Investigaciones Biomédicas de la Universidad de Carabobo (BIOMED-UC), Maracay, Venezuela

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  • Isabel Bazan,

    Affiliation: US Naval Medical Research Unit No. 6, Lima, Peru

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  • Claudio Rocha,

    Affiliation: US Naval Medical Research Unit No. 6, Lima, Peru

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  • Stalin Vilcarromero,

    Affiliation: US Naval Medical Research Unit No. 6, Lima, Peru

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  • Patrick J. Blair,

    Affiliation: US Naval Medical Research Unit No. 2 – Pacific, American Embassy Singapore, Singapore

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  • Thomas W. Scott,

    Affiliation: Department of Entomology, University of California at Davis, Davis, California, United States of America

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  • Daria E. Camacho,

    Affiliation: Laboratorio Regional de Diagnóstico e Investigación del Dengue y otras Enfermedades Virales (LARDIDEV), Instituto de Investigaciones Biomédicas de la Universidad de Carabobo (BIOMED-UC), Maracay, Venezuela

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  • Christian F. Ockenhouse,

    Affiliation: Division of Malaria Vaccine Development, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America

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  • Eric S. Halsey,

    Affiliation: US Naval Medical Research Unit No. 6, Lima, Peru

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  • Tadeusz J. Kochel

    Affiliation: Naval Medical Research Center, Silver Spring, Maryland, United States of America

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  • Published: July 11, 2013
  • DOI: 10.1371/journal.pntd.0002298

About the Authors

Peifang Sun, Tadeusz J. Kochel
Naval Medical Research Center, Silver Spring, Maryland, United States of America
Peifang Sun, Zhining Wang
Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland, United States of America
Josefina García, Brett M. Forshey, Amy C. Morrison, Isabel Bazan, Claudio Rocha, Stalin Vilcarromero, Eric S. Halsey
US Naval Medical Research Unit No. 6, Lima, Peru
Guillermo Comach, Gloria Sierra, Daria E. Camacho
Laboratorio Regional de Diagnóstico e Investigación del Dengue y otras Enfermedades Virales (LARDIDEV), Instituto de Investigaciones Biomédicas de la Universidad de Carabobo (BIOMED-UC), Maracay, Venezuela
Maryanne T. Vahey
Division of Retrovirology, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America
Amy C. Morrison, Thomas W. Scott
Department of Entomology, University of California at Davis, Davis, California, United States of America
Patrick J. Blair
US Naval Medical Research Unit No. 2 – Pacific, American Embassy Singapore, Singapore
Christian F. Ockenhouse
Division of Malaria Vaccine Development, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America

Corresponding Author

Email: peifang.sun@med.navy.mil

Competing Interests

None of the authors has a financial or personal conflict of interest related to this study. The corresponding author had full access to all data in the study and final responsibility for the decision to submit this publication.

Author Contributions

Conceived and designed the experiments: PJB CFO TJK. Performed the experiments: MTV ZW. Analyzed the data: PS JG MTV ZW. Contributed reagents/materials/analysis tools: GC GS IB SV DEC. Wrote the paper: PS JG. Critical review of the manuscript: JG GC BMF ACM CR PJB ESH TJK TWS. Project Coordinator: ESH TJK. Field coordinator: GC.