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Research Article

Overexpression of the Endothelial Protein C Receptor Is Detrimental during Pneumonia-Derived Gram-negative Sepsis (Melioidosis)

  • Liesbeth M. Kager mail,

    l.m.kager@amc.uva.nl

    Affiliations: Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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  • Marcel Schouten,

    Affiliations: Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

    X
  • W. Joost Wiersinga,

    Affiliations: Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, Department of Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

    X
  • J. Daan de Boer,

    Affiliations: Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

    X
  • Lionel C. W. Lattenist,

    Affiliation: Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

    X
  • Joris J. T. H. Roelofs,

    Affiliation: Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

    X
  • Joost C. M. Meijers,

    Affiliation: Department of Experimental Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

    X
  • Marcel Levi,

    Affiliation: Department of Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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  • Arjen M. Dondorp,

    Affiliations: Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford, United Kingdom

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  • Charles T. Esmon,

    Affiliation: Oklahoma Medical Research Foundation, Howard Hughes Medical Institute, Oklahoma City, Oklahoma, United States of America

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  • Cornelis van 't Veer,

    Affiliations: Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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  • Tom van der Poll

    Affiliations: Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, Department of Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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  • Published: July 11, 2013
  • DOI: 10.1371/journal.pntd.0002306

About the Authors

Liesbeth M. Kager, Marcel Schouten, W. Joost Wiersinga, J. Daan de Boer, Cornelis van 't Veer, Tom van der Poll
Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Liesbeth M. Kager, Marcel Schouten, W. Joost Wiersinga, J. Daan de Boer, Cornelis van 't Veer, Tom van der Poll
Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
W. Joost Wiersinga, Marcel Levi, Tom van der Poll
Department of Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Lionel C. W. Lattenist, Joris J. T. H. Roelofs
Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Joost C. M. Meijers
Department of Experimental Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Arjen M. Dondorp
Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Arjen M. Dondorp
Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford, United Kingdom
Charles T. Esmon
Oklahoma Medical Research Foundation, Howard Hughes Medical Institute, Oklahoma City, Oklahoma, United States of America

Corresponding Author

Email: l.m.kager@amc.uva.nl

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LMK WJW CvV TvdP. Performed the experiments: LMK MS JDdB LCWL JJTHR ML JCMM. Analyzed the data: LMK JJTHR JCMM CvV TvdP. Contributed reagents/materials/analysis tools: JCMM ML AMD CTE. Wrote the paper: LMK MS WJW JDdB LCWL JJTHR JCMM ML AMD CTE CvV TvdP.