Advertisement
Research Article

Cathelicidin-like Helminth Defence Molecules (HDMs): Absence of Cytotoxic, Anti-microbial and Anti-protozoan Activities Imply a Specific Adaptation to Immune Modulation

  • Karine Thivierge equal contributor,

    equal contributor Contributed equally to this work with: Karine Thivierge, Sophie Cotton

    Affiliations: Institute of Parasitology, McGill University, Sainte-Anne-de-Bellevue, Quebec, Canada, Laboratoire de Santé Publique du Québec, Institut National de Santé Publique du Québec, Sainte-Anne-de-Bellevue, Quebec, Canada

    X
  • Sophie Cotton equal contributor,

    equal contributor Contributed equally to this work with: Karine Thivierge, Sophie Cotton

    Affiliation: Institute of Parasitology, McGill University, Sainte-Anne-de-Bellevue, Quebec, Canada

    X
  • Deborah A. Schaefer,

    Affiliation: Department of Veterinary Science and Microbiology, University of Arizona, Tucson, Arizona, United States of America

    X
  • Michael W. Riggs,

    Affiliation: Department of Veterinary Science and Microbiology, University of Arizona, Tucson, Arizona, United States of America

    X
  • Joyce To,

    Affiliation: The ithree Institute, University of Technology Sydney (UTS), Sydney, Australia

    X
  • Maria E. Lund,

    Affiliation: The ithree Institute, University of Technology Sydney (UTS), Sydney, Australia

    X
  • Mark W. Robinson,

    Affiliations: The ithree Institute, University of Technology Sydney (UTS), Sydney, Australia, School of Biological Sciences, Queen's University Belfast, Medical Biology Centre, Belfast, Northern Ireland

    X
  • John P. Dalton,

    Affiliation: Institute of Parasitology, McGill University, Sainte-Anne-de-Bellevue, Quebec, Canada

    X
  • Sheila M. Donnelly mail

    Sheila.Donnelly@uts.edu.au

    Affiliation: The ithree Institute, University of Technology Sydney (UTS), Sydney, Australia

    X
  • Published: July 11, 2013
  • DOI: 10.1371/journal.pntd.0002307

About the Authors

Karine Thivierge, Sophie Cotton, John P. Dalton
Institute of Parasitology, McGill University, Sainte-Anne-de-Bellevue, Quebec, Canada
Karine Thivierge
Laboratoire de Santé Publique du Québec, Institut National de Santé Publique du Québec, Sainte-Anne-de-Bellevue, Quebec, Canada
Deborah A. Schaefer, Michael W. Riggs
Department of Veterinary Science and Microbiology, University of Arizona, Tucson, Arizona, United States of America
Joyce To, Maria E. Lund, Mark W. Robinson, Sheila M. Donnelly
The ithree Institute, University of Technology Sydney (UTS), Sydney, Australia
Mark W. Robinson
School of Biological Sciences, Queen's University Belfast, Medical Biology Centre, Belfast, Northern Ireland

Corresponding Author

Email: Sheila.Donnelly@uts.edu.au

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: K. Thivierge, S. Cotton, M. Riggs, M. Robinson, J. Dalton, S. Donnelly. Performed the experiments: K. Thivierge, S. Cotton, D. Schaefer, M. Riggs, J. To, M. Lund, M. Robinson, S. Donnelly. Analyzed the data: K. Thivierge, S. Cotton, D. Schaefer, M. Riggs, J. To, M. Lund, M. Robinson, J. Dalton, S. Donnelly. Contributed reagents/materials/analysis tools: M. Riggs, J. Dalton. Wrote the paper: K. Thivierge, S. Cotton, D. Schaefer, M. Riggs, J. To, M. Lund, M. Robinson, J. Dalton, S. Donnelly.