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Research Article

A Single Immunization with MVA Expressing GnGc Glycoproteins Promotes Epitope-specific CD8+-T Cell Activation and Protects Immune-competent Mice against a Lethal RVFV Infection

  • Elena López-Gil,

    Affiliation: Centro de Investigación en Sanidad Animal, INIA, Valdeolmos, Madrid, Spain

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  • Gema Lorenzo,

    Affiliation: Centro de Investigación en Sanidad Animal, INIA, Valdeolmos, Madrid, Spain

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  • Esther Hevia,

    Affiliation: Centro de Investigación en Sanidad Animal, INIA, Valdeolmos, Madrid, Spain

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  • Belén Borrego,

    Affiliation: Centro de Investigación en Sanidad Animal, INIA, Valdeolmos, Madrid, Spain

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  • Martin Eiden,

    Affiliation: Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany

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  • Martin Groschup,

    Affiliation: Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany

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  • Sarah C. Gilbert,

    Affiliation: Jenner Institute, University of Oxford, Oxford, United Kingdom

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  • Alejandro Brun mail

    brun@inia.es

    Affiliation: Centro de Investigación en Sanidad Animal, INIA, Valdeolmos, Madrid, Spain

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  • Published: July 11, 2013
  • DOI: 10.1371/journal.pntd.0002309

About the Authors

Elena López-Gil, Gema Lorenzo, Esther Hevia, Belén Borrego, Alejandro Brun
Centro de Investigación en Sanidad Animal, INIA, Valdeolmos, Madrid, Spain
Martin Eiden, Martin Groschup
Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany
Sarah C. Gilbert
Jenner Institute, University of Oxford, Oxford, United Kingdom

Corresponding Author

Email: brun@inia.es

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AB ELG GL BB SCG. Performed the experiments: GL ELG BB EH. Analyzed the data: AB ELG GL. Contributed reagents/materials/analysis tools: ME MG SCG. Wrote the paper: AB GL ELG.