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Research Article

Evaluation of a Typhoid/Paratyphoid Diagnostic Assay (TPTest) Detecting Anti-Salmonella IgA in Secretions of Peripheral Blood Lymphocytes in Patients in Dhaka, Bangladesh

  • Farhana Khanam,

    Affiliation: International Centre for Diarrhoeal Disease Research (icddr,b), Bangladesh, Dhaka, Bangladesh

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  • Alaullah Sheikh,

    Affiliation: International Centre for Diarrhoeal Disease Research (icddr,b), Bangladesh, Dhaka, Bangladesh

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  • Md. Abu Sayeed,

    Affiliation: International Centre for Diarrhoeal Disease Research (icddr,b), Bangladesh, Dhaka, Bangladesh

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  • Md. Saruar Bhuiyan,

    Affiliation: International Centre for Diarrhoeal Disease Research (icddr,b), Bangladesh, Dhaka, Bangladesh

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  • Feroza Kaneez Choudhury,

    Affiliation: International Centre for Diarrhoeal Disease Research (icddr,b), Bangladesh, Dhaka, Bangladesh

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  • Umme Salma,

    Affiliation: International Centre for Diarrhoeal Disease Research (icddr,b), Bangladesh, Dhaka, Bangladesh

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  • Shahnaz Pervin,

    Affiliation: Department of Microbiology, Dhaka Medical College and Hospital (DMCH), Dhaka, Bangladesh

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  • Tania Sultana,

    Affiliation: International Centre for Diarrhoeal Disease Research (icddr,b), Bangladesh, Dhaka, Bangladesh

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  • Dilruba Ahmed,

    Affiliation: International Centre for Diarrhoeal Disease Research (icddr,b), Bangladesh, Dhaka, Bangladesh

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  • Doli Goswami,

    Affiliation: International Centre for Diarrhoeal Disease Research (icddr,b), Bangladesh, Dhaka, Bangladesh

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  • Md. Lokman Hossain,

    Affiliation: International Centre for Diarrhoeal Disease Research (icddr,b), Bangladesh, Dhaka, Bangladesh

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  • K. Z. Mamun,

    Affiliation: Department of Microbiology, Dhaka Medical College and Hospital (DMCH), Dhaka, Bangladesh

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  • Richelle C. Charles,

    Affiliations: Division of Infectious Disease, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

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  • W. Abdullah Brooks,

    Affiliation: International Centre for Diarrhoeal Disease Research (icddr,b), Bangladesh, Dhaka, Bangladesh

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  • Stephen B. Calderwood,

    Affiliations: Division of Infectious Disease, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Alejandro Cravioto,

    Affiliation: International Vaccine Institute, Seoul, South Korea

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  • Edward T. Ryan ,

    Affiliations: Division of Infectious Disease, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America

    These authors are joint senior authors on this work.

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  • Firdausi Qadri mail

    fqadri@icddrb.org

    Affiliation: International Centre for Diarrhoeal Disease Research (icddr,b), Bangladesh, Dhaka, Bangladesh

    These authors are joint senior authors on this work.

    X
  • Published: July 11, 2013
  • DOI: 10.1371/journal.pntd.0002316

About the Authors

Farhana Khanam, Alaullah Sheikh, Md. Abu Sayeed, Md. Saruar Bhuiyan, Feroza Kaneez Choudhury, Umme Salma, Tania Sultana, Dilruba Ahmed, Doli Goswami, Md. Lokman Hossain, W. Abdullah Brooks, Firdausi Qadri
International Centre for Diarrhoeal Disease Research (icddr,b), Bangladesh, Dhaka, Bangladesh
Shahnaz Pervin, K. Z. Mamun
Department of Microbiology, Dhaka Medical College and Hospital (DMCH), Dhaka, Bangladesh
Richelle C. Charles, Stephen B. Calderwood, Edward T. Ryan
Division of Infectious Disease, Massachusetts General Hospital, Boston, Massachusetts, United States of America
Richelle C. Charles, Stephen B. Calderwood, Edward T. Ryan
Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
Stephen B. Calderwood
Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, United States of America
Edward T. Ryan
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America
Alejandro Cravioto
International Vaccine Institute, Seoul, South Korea

Corresponding Author

Email: fqadri@icddrb.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: FK AS SBC ETR FQ. Performed the experiments: FK AS MAS MSB FKC US SP TS. Analyzed the data: FK AS MAS MSB FKC. Contributed reagents/materials/analysis tools: DA DG MLH KZM RCC WAB SBC AC ETR FQ. Wrote the paper: FK AS SBC ETR FQ.