Advertisement
Research Article

TLR9 Activation Dampens the Early Inflammatory Response to Paracoccidioides brasiliensis, Impacting Host Survival

  • João Filipe Menino,

    Affiliations: Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal, ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal

    X
  • Margarida Saraiva,

    Affiliations: Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal, ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal

    X
  • Ana G. Gomes-Alves,

    Affiliations: Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal, ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal

    X
  • Diogo Lobo-Silva,

    Affiliations: Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal, ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal

    X
  • Mark Sturme,

    Affiliations: Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal, ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal

    X
  • Jéssica Gomes-Rezende,

    Affiliations: Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal, ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal

    X
  • Ana Laura Saraiva,

    Affiliation: EUVG - Escola Universitária Vasco da Gama, Castelo Viegas, Coimbra, Portugal

    X
  • Gustavo H. Goldman,

    Affiliation: Laboratório Nacional de Ciência e Tecnologia do Bioetanol – CTBE, Campinas, São Paulo, Brazil, and Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brasil

    X
  • Cristina Cunha,

    Affiliation: Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy

    X
  • Agostinho Carvalho,

    Affiliation: Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy

    X
  • Luigina Romani,

    Affiliation: Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy

    X
  • Jorge Pedrosa,

    Affiliations: Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal, ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal

    X
  • António Gil Castro,

    Affiliations: Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal, ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal

    X
  • Fernando Rodrigues mail

    frodrigues@ecsaude.uminho.pt

    Affiliations: Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal, ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal

    X
  • Published: July 25, 2013
  • DOI: 10.1371/journal.pntd.0002317

About the Authors

João Filipe Menino, Margarida Saraiva, Ana G. Gomes-Alves, Diogo Lobo-Silva, Mark Sturme, Jéssica Gomes-Rezende, Jorge Pedrosa, António Gil Castro, Fernando Rodrigues
Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal
João Filipe Menino, Margarida Saraiva, Ana G. Gomes-Alves, Diogo Lobo-Silva, Mark Sturme, Jéssica Gomes-Rezende, Jorge Pedrosa, António Gil Castro, Fernando Rodrigues
ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal
Ana Laura Saraiva
EUVG - Escola Universitária Vasco da Gama, Castelo Viegas, Coimbra, Portugal
Gustavo H. Goldman
Laboratório Nacional de Ciência e Tecnologia do Bioetanol – CTBE, Campinas, São Paulo, Brazil, and Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brasil
Cristina Cunha, Agostinho Carvalho, Luigina Romani
Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy

Corresponding Author

Email: frodrigues@ecsaude.uminho.pt

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: M. Saraiva, A. Carvalho, A.G. Castro, F. Rodrigues. Performed the experiments: J.F. Menino, A.G. Gomes-Alves, D. Lobo-Silva, M. Sturme, G.H. Goldman, J. Gomes-Rezende, A.L. Saraiva, J. Pedrosa. Analyzed the data: J.F. Menino, C. Cunha, A. Carvalho, L. Romani, A.G. Castro, F. Rodrigues. Contributed reagents/materials/analysis tools: F. Rodrigues. Wrote the paper: J.F. Menino, M. Saraiva, A.G. Castro, F. Rodrigues.