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Research Article

Targeting the Non-structural Protein 1 from Dengue Virus to a Dendritic Cell Population Confers Protective Immunity to Lethal Virus Challenge

  • Hugo R. Henriques equal contributor,

    equal contributor Contributed equally to this work with: Hugo R. Henriques, Eline V. Rampazo

    Affiliation: Laboratory of Antigen Targeting to Dendritic Cells, Department of Parasitology, University of São Paulo, São Paulo, Brazil

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  • Eline V. Rampazo equal contributor,

    equal contributor Contributed equally to this work with: Hugo R. Henriques, Eline V. Rampazo

    Affiliation: Laboratory of Antigen Targeting to Dendritic Cells, Department of Parasitology, University of São Paulo, São Paulo, Brazil

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  • Antonio J. S. Gonçalves,

    Affiliation: Laboratory of Biotechnology and Physiology of Viral Infections, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil

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  • Elaine C. M. Vicentin,

    Affiliation: Laboratory of Antigen Targeting to Dendritic Cells, Department of Parasitology, University of São Paulo, São Paulo, Brazil

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  • Jaime H. Amorim,

    Affiliation: Laboratory of Vaccine Development, Department of Microbiology, University of São Paulo, São Paulo, Brazil

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  • Raquel H. Panatieri,

    Affiliation: Laboratory of Antigen Targeting to Dendritic Cells, Department of Parasitology, University of São Paulo, São Paulo, Brazil

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  • Kelly N. S. Amorim,

    Affiliation: Laboratory of Antigen Targeting to Dendritic Cells, Department of Parasitology, University of São Paulo, São Paulo, Brazil

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  • Marcio M. Yamamoto,

    Affiliation: Laboratory of Antigen Targeting to Dendritic Cells, Department of Parasitology, University of São Paulo, São Paulo, Brazil

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  • Luís C. S. Ferreira,

    Affiliations: Laboratory of Vaccine Development, Department of Microbiology, University of São Paulo, São Paulo, Brazil, National Institute for Science and Technology in Vaccines, Belo Horizonte, Brazil

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  • Ada M. B. Alves,

    Affiliations: Laboratory of Biotechnology and Physiology of Viral Infections, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, National Institute for Science and Technology in Vaccines, Belo Horizonte, Brazil

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  • Silvia B. Boscardin mail

    sbboscardin@usp.br

    Affiliations: Laboratory of Antigen Targeting to Dendritic Cells, Department of Parasitology, University of São Paulo, São Paulo, Brazil, National Institute for Science and Technology in Vaccines, Belo Horizonte, Brazil

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  • Published: July 18, 2013
  • DOI: 10.1371/journal.pntd.0002330

About the Authors

Hugo R. Henriques, Eline V. Rampazo, Elaine C. M. Vicentin, Raquel H. Panatieri, Kelly N. S. Amorim, Marcio M. Yamamoto, Silvia B. Boscardin
Laboratory of Antigen Targeting to Dendritic Cells, Department of Parasitology, University of São Paulo, São Paulo, Brazil
Antonio J. S. Gonçalves, Ada M. B. Alves
Laboratory of Biotechnology and Physiology of Viral Infections, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil
Jaime H. Amorim, Luís C. S. Ferreira
Laboratory of Vaccine Development, Department of Microbiology, University of São Paulo, São Paulo, Brazil
Luís C. S. Ferreira, Ada M. B. Alves, Silvia B. Boscardin
National Institute for Science and Technology in Vaccines, Belo Horizonte, Brazil

Corresponding Author

Email: sbboscardin@usp.br

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SBB HRH AMBA LCSF. Performed the experiments: SBB HRH EVR AJSG JHA KNSA RHP ECMV. Analyzed the data: HRH SBB AMBA. Contributed reagents/materials/analysis tools: MMY AMBA AJSG JHA LCSF SBB. Wrote the paper: SBB LCSF.