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Research Article

Chikungunya Virus Infection Results in Higher and Persistent Viral Replication in Aged Rhesus Macaques Due to Defects in Anti-Viral Immunity

  • Ilhem Messaoudi mail,

    messaoud@ucr.edu (IM); streblow@ohsu.edu (DNS)

    Affiliations: Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America, Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon, United States of America, Division of Pathobiology and Immunology, Oregon National Primate Research Center, Beaverton, Oregon, United States of America

    Current address: University of California-Riverside, Riverside, California, United States of America

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  • Jennifer Vomaske,

    Affiliations: Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America, Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon, United States of America

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  • Thomas Totonchy,

    Affiliation: Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon, United States of America

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  • Craig N. Kreklywich,

    Affiliation: Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America

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  • Kristen Haberthur,

    Affiliations: Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America, Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon, United States of America, Division of Pathobiology and Immunology, Oregon National Primate Research Center, Beaverton, Oregon, United States of America

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  • Laura Springgay,

    Affiliations: Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America, Division of Pathobiology and Immunology, Oregon National Primate Research Center, Beaverton, Oregon, United States of America

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  • James D. Brien,

    Affiliation: Departments of Molecular Microbiology, Medicine, Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Michael S. Diamond,

    Affiliation: Departments of Molecular Microbiology, Medicine, Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Victor R. DeFilippis,

    Affiliations: Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America, Division of Pathobiology and Immunology, Oregon National Primate Research Center, Beaverton, Oregon, United States of America

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  • Daniel N. Streblow mail

    messaoud@ucr.edu (IM); streblow@ohsu.edu (DNS)

    Affiliations: Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America, Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon, United States of America, Division of Pathobiology and Immunology, Oregon National Primate Research Center, Beaverton, Oregon, United States of America

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  • Published: July 25, 2013
  • DOI: 10.1371/journal.pntd.0002343

About the Authors

Ilhem Messaoudi, Jennifer Vomaske, Craig N. Kreklywich, Kristen Haberthur, Laura Springgay, Victor R. DeFilippis, Daniel N. Streblow
Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America
Ilhem Messaoudi, Jennifer Vomaske, Thomas Totonchy, Kristen Haberthur, Daniel N. Streblow
Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon, United States of America
Ilhem Messaoudi, Kristen Haberthur, Laura Springgay, Victor R. DeFilippis, Daniel N. Streblow
Division of Pathobiology and Immunology, Oregon National Primate Research Center, Beaverton, Oregon, United States of America
James D. Brien, Michael S. Diamond
Departments of Molecular Microbiology, Medicine, Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: IM JV MSD VRDF DNS. Performed the experiments: JV TT CNK KH LS JDB DNS. Analyzed the data: IM JV MSD DNS. Contributed reagents/materials/analysis tools: IM MSD VRDF DNS. Wrote the paper: IM DNS.