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Research Article

A High Force of Plasmodium vivax Blood-Stage Infection Drives the Rapid Acquisition of Immunity in Papua New Guinean Children

  • Cristian Koepfli,

    Affiliations: Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland, Walter and Eliza Hall Institute, Parkville, Victoria, Australia

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  • Kathryn L. Colborn,

    Affiliations: Walter and Eliza Hall Institute, Parkville, Victoria, Australia, University of California, Berkeley, Department of Biostatistics, Berkeley, California, United States of America

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  • Benson Kiniboro,

    Affiliation: Papua New Guinea Institute of Medical Research, Goroka, Eastern Highland Province, Papua New Guinea

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  • Enmoore Lin,

    Affiliation: Papua New Guinea Institute of Medical Research, Goroka, Eastern Highland Province, Papua New Guinea

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  • Terence P. Speed,

    Affiliation: Walter and Eliza Hall Institute, Parkville, Victoria, Australia

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  • Peter M. Siba,

    Affiliation: Papua New Guinea Institute of Medical Research, Goroka, Eastern Highland Province, Papua New Guinea

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  • Ingrid Felger mail,

    ingrid.felger@unibas.ch (IF); ivomueller@fastmail.fm (IM)

    Affiliations: Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland

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  • Ivo Mueller mail

    ingrid.felger@unibas.ch (IF); ivomueller@fastmail.fm (IM)

    Affiliations: Walter and Eliza Hall Institute, Parkville, Victoria, Australia, Papua New Guinea Institute of Medical Research, Goroka, Eastern Highland Province, Papua New Guinea, Barcelona Centre for International Health Research, Barcelona, Spain

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  • Published: September 05, 2013
  • DOI: 10.1371/journal.pntd.0002403

About the Authors

Cristian Koepfli, Ingrid Felger
Swiss Tropical and Public Health Institute, Basel, Switzerland
Cristian Koepfli, Ingrid Felger
University of Basel, Basel, Switzerland
Cristian Koepfli, Kathryn L. Colborn, Terence P. Speed, Ivo Mueller
Walter and Eliza Hall Institute, Parkville, Victoria, Australia
Kathryn L. Colborn
University of California, Berkeley, Department of Biostatistics, Berkeley, California, United States of America
Benson Kiniboro, Enmoore Lin, Peter M. Siba, Ivo Mueller
Papua New Guinea Institute of Medical Research, Goroka, Eastern Highland Province, Papua New Guinea
Ivo Mueller
Barcelona Centre for International Health Research, Barcelona, Spain

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: IM IF. Performed the experiments: CK BK EL. Analyzed the data: CK KLC TPS IM. Contributed reagents/materials/analysis tools: PMS. Wrote the paper: CK IM IF KLC TPS.