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Research Article

Transcriptome Analysis of Human Peripheral Blood Mononuclear Cells Exposed to Lassa Virus and to the Attenuated Mopeia/Lassa Reassortant 29 (ML29), a Vaccine Candidate

  • Juan Carlos Zapata mail,

    jczapata@ihv.umaryland.edu

    Affiliation: Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

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  • Ricardo Carrion Jr,

    Affiliation: Texas Biomedical Research Institute, San Antonio, Texas, United States of America

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  • Jean L. Patterson,

    Affiliation: Texas Biomedical Research Institute, San Antonio, Texas, United States of America

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  • Oswald Crasta,

    Affiliation: Virginia Bioinformatics Institute at Virginia Tech, Blacksburg, Virginia, United States of America

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  • Yan Zhang,

    Affiliation: Virginia Bioinformatics Institute at Virginia Tech, Blacksburg, Virginia, United States of America

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  • Sachin Mani,

    Affiliation: Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America

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  • Marti Jett,

    Affiliation: Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America

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  • Bhawna Poonia,

    Affiliation: Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

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  • Mahmoud Djavani,

    Affiliation: Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

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  • David M. White,

    Affiliation: Center for Disease Control and Prevention, Atlanta, Georgia, United States of America

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  • Igor S. Lukashevich ,

    Affiliation: Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

    Current address: Center for Predictive Medicine, University of Louisville, Louisville, Kentucky, United States of America.

    ISL and MSS are co-senior authors.

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  • Maria S. Salvato

    Affiliation: Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

    ISL and MSS are co-senior authors.

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  • Published: September 12, 2013
  • DOI: 10.1371/journal.pntd.0002406

About the Authors

Juan Carlos Zapata, Bhawna Poonia, Mahmoud Djavani, Igor S. Lukashevich, Maria S. Salvato
Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
Ricardo Carrion Jr, Jean L. Patterson
Texas Biomedical Research Institute, San Antonio, Texas, United States of America
Oswald Crasta, Yan Zhang
Virginia Bioinformatics Institute at Virginia Tech, Blacksburg, Virginia, United States of America
Sachin Mani, Marti Jett
Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America
David M. White
Center for Disease Control and Prevention, Atlanta, Georgia, United States of America

Corresponding Author

Email: jczapata@ihv.umaryland.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JCZ ISL MSS. Performed the experiments: JCZ SM BP RC DMW. Analyzed the data: JCZ OC YZ MD ISL MSS. Contributed reagents/materials/analysis tools: MJ JLP OC YZ. Wrote the paper: JCZ ISL MSS.